{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:50:39Z","timestamp":1769604639229,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R33"],"award-info":[{"award-number":["PNURSP2022R33"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Green synthesis of nanoparticles has emerged as an effective and environmentally friendly method. Therefore, the current investigation is based on the green synthesis of zinc oxide nanoparticles (ZnO\u2010NPs) using plant extract of <jats:italic>Sanvitalia procumbens<\/jats:italic> (<jats:italic>S. procumbens<\/jats:italic>) that act as a capping and reducing agent. <jats:italic>S. procumbens<\/jats:italic> is a fast\u2010growing shrub and densely available plant and may have potential to synthesize ZnO\u2010NPs. The synthesized ZnO\u2010NPs were characterized by different techniques, including Fourier transform infrared spectroscopy (FT\u2010IR), UV\u2010visible (UV\u2010Vis), energy\u2010dispersive X\u2010ray (EDX), X\u2010ray diffraction (XRD), and scanning electron microscopy (SEM). The UV\u2010Vis spectrum at 350\u2009nm revealed an absorption peak for the synthesis of ZnO\u2010NPs. In addition, photoactive biomolecules of the prepared ZnO\u2010NPs were identified by using FT\u2010IR spectroscopy. Furthermore, the spherical geometry of ZnO\u2010NPs was evaluated by SEM images. The synthesized ZnO\u2010NPs were also used to enhance the antidepressant activity and exhibited a remarkable reduction in the time of immobility in tail suspension tests (TST) and forced swim tests (FST), as well as increased the BDNF levels in the brain and plasma. ZnO\u2010NPs have a low risk of biocompatibility (cell visibility) at a concentration of 7\u2009g\/mL or below. The nanoparticles were biologically compatible when the concentrations were increased up to 11\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. It was concluded that ZnO\u2010NPs were investigated as a possible carrier for antidepressant drug delivery into the brain, and their excellent cytotoxic activity was evaluated by using the MTT assay to determine their biocompatibility.<\/jats:p>","DOI":"10.1155\/2022\/1621372","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T23:20:30Z","timestamp":1655421630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["[Retracted] Affective Antidepressant, Cytotoxic Activities, and Characterization of Phyto\u2010Assisted Zinc Oxide Nanoparticles Synthesized Using Sanvitalia procumbens Aqueous Extract"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yasir","family":"Rashid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-7427","authenticated-orcid":false,"family":"Fozia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-1611","authenticated-orcid":false,"given":"Ijaz","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeeha","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-447X","authenticated-orcid":false,"given":"Amal","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2009.04.008"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060835"},{"key":"e_1_2_10_3_2","first-page":"1177","article-title":"An overview on uses of zinc oxide nanoparticles","volume":"4","author":"Bedi P.","year":"2015","journal-title":"World Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA04424H"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2021.105366"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.060"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/29\/295103"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.4194"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2014.01.005"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.12.096"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5589703"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2017.05.351"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2020.e00427"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA05693A"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2015.03.176"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.08.033"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12738"},{"key":"e_1_2_10_18_2","article-title":"Solid lipid nanoparticles","volume":"2","author":"Ekambaram P.","year":"2012","journal-title":"Science Review and Chemical Communication"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-8854-4_19"},{"key":"e_1_2_10_20_2","unstructured":"Perez-OchoaM. 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