{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:15:26Z","timestamp":1791598526496,"version":"4.3.4"},"reference-count":166,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Funding of China","award":["81802238"],"award-info":[{"award-number":["81802238"]}]},{"name":"National Natural Science Funding of China","award":["2021KY1075"],"award-info":[{"award-number":["2021KY1075"]}]},{"name":"National Natural Science Funding of China","award":["2020KY908"],"award-info":[{"award-number":["2020KY908"]}]},{"name":"National Natural Science Funding of China","award":["2019KY646"],"award-info":[{"award-number":["2019KY646"]}]},{"name":"Science and Technology Project of Zhejiang Health Committee","award":["81802238"],"award-info":[{"award-number":["81802238"]}]},{"name":"Science and Technology Project of Zhejiang Health Committee","award":["2021KY1075"],"award-info":[{"award-number":["2021KY1075"]}]},{"name":"Science and Technology Project of Zhejiang Health Committee","award":["2020KY908"],"award-info":[{"award-number":["2020KY908"]}]},{"name":"Science and Technology Project of Zhejiang Health Committee","award":["2019KY646"],"award-info":[{"award-number":["2019KY646"]}]},{"DOI":"10.13039\/501100017594","name":"Medical and Health Science and Technology Project of Zhejiang Province","doi-asserted-by":"crossref","award":["81802238"],"award-info":[{"award-number":["81802238"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Medical and Health Science and Technology Project of Zhejiang Province","doi-asserted-by":"crossref","award":["2021KY1075"],"award-info":[{"award-number":["2021KY1075"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Medical and Health Science and Technology Project of Zhejiang Province","doi-asserted-by":"crossref","award":["2020KY908"],"award-info":[{"award-number":["2020KY908"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Medical and Health Science and Technology Project of Zhejiang Province","doi-asserted-by":"crossref","award":["2019KY646"],"award-info":[{"award-number":["2019KY646"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Microtubules (MTs) are highly dynamic polymers essential for a wide range of cellular physiologies, such as acting as directional railways for intracellular transport and position, guiding chromosome segregation during cell division, and controlling cell polarity and morphogenesis. Evidence has established that maintaining microtubule (MT) stability in neurons is vital for fundamental cellular and developmental processes, such as neurodevelopment, degeneration, and regeneration. To fulfill these diverse functions, the nervous system employs an arsenal of microtubule\u2010associated proteins (MAPs) to control MT organization and function. Subsequent studies have identified that the disruption of MT function in neurons is one of the most prevalent and important pathological features of traumatic nerve damage and neurodegenerative diseases and that this disruption manifests as a reduction in MT polymerization and concomitant deregulation of the MT cytoskeleton, as well as downregulation of microtubule\u2010associated protein (MAP) expression. A variety of MT\u2010targeting agents that reverse this pathological condition, which is regarded as a therapeutic opportunity to intervene the onset and development of these nervous system abnormalities, is currently under development. Here, we provide an overview of the MT\u2010intrinsic organization process and how MAPs interact with the MT cytoskeleton to promote MT polymerization, stabilization, and bundling. We also highlight recent advances in MT\u2010targeting therapeutic agents applied to various neurological disorders. Together, these findings increase our current understanding of the function and regulation of MT organization in nerve growth and regeneration.<\/jats:p>","DOI":"10.1155\/2022\/1623181","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:50:23Z","timestamp":1646715023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Microtubule Organization Is Essential for Maintaining Cellular Morphology and Function"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-891X","authenticated-orcid":false,"given":"Lijiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-7056","authenticated-orcid":false,"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-0133","authenticated-orcid":false,"given":"Xuetao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-8306","authenticated-orcid":false,"given":"Xiaoxiao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-621X","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-4544","authenticated-orcid":false,"given":"Yongsheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-3415","authenticated-orcid":false,"given":"Wei","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0703-599"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00626"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.75"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001450"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2016.1241923"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw9997"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.07.004"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.11.018"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22746"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21300"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.13.1.83"},{"key":"e_1_2_13_12_2","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2014.00511","article-title":"The role of dynamic instability in microtubule organization","volume":"5","author":"Horio T.","year":"2014","journal-title":"Frontiers in Plant Science"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2015.09.004"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e15-11-0769"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.1.3"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1112614"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20180028"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.10.004"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.05.058"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022608"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309958110"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03069"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020357"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.06.048"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.02.014"},{"key":"e_1_2_13_26_2","article-title":"The MAP2\/Tau family of microtubule-associated proteins","volume":"6","author":"Dehmelt L.","year":"2005","journal-title":"Genome Biology"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.295"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.046"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9030105"},{"key":"e_1_2_13_30_2","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.590059","article-title":"Much more than a sytoskeletal protein: physiological and pathological functions of the non-microtubule binding region of Tau","volume":"11","author":"Brandt R.","year":"2020","journal-title":"Frontiers in Neurology"},{"key":"e_1_2_13_31_2","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.647054","article-title":"Tau: a signaling hub protein","volume":"14","author":"Mueller R. L.","year":"2021","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"e_1_2_13_32_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22501-9","article-title":"Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice","author":"Caballero B.","year":"2021","journal-title":"Nature Communications"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e14-06-1099"},{"key":"e_1_2_13_34_2","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00256","article-title":"The evolution of Tau phosphorylation and interactions","volume":"11","author":"Trushina N. I.","year":"2019","journal-title":"Frontiers in aging Neuroscience"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504081112"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.640"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.03.003"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02079-x"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77115-w"},{"key":"e_1_2_13_40_2","article-title":"Doublecortin (DCX) is not essential for survival and differentiation of newborn neurons in the adult mouse dentate gyrus","volume":"9","author":"Dhaliwal J.","year":"2015","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2471-19.2020"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4851-09.2010"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616393114"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.046"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5205"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13247-6"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.005"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.037"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801820115"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.10.042"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13064-017-0082-5"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.227850"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404133111"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.12.027"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.12.056"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803875115"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21286"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.08.032"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2017.03.008"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-04-01454.1988"},{"key":"e_1_2_13_61_2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56547","article-title":"Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites","volume":"9","author":"Liang X.","year":"2020","journal-title":"Elife"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10266"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2017.03.001"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.12.002"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2020.03.010"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1007-1110"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.042309"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.01.003"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.01.003"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e17-06-0380"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.02.005"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.11.004"},{"key":"e_1_2_13_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.039"},{"key":"e_1_2_13_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.02.003"},{"key":"e_1_2_13_75_2","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.594199","article-title":"Distinct microtubule organizing center mechanisms combine to generate neuron polarity and arbor complexity","volume":"14","author":"Wilkes O. R.","year":"2020","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.022"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24376-2"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.04.040"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2014"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.09.019"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.05.007"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.06.026"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.02.017"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5425-12.2013"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201505011"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.11.001"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718755778"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-014-1444-6"},{"key":"e_1_2_13_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13064-019-0134-0"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.02.024"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1865"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0612-07.2007"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8764"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2016-0160"},{"key":"e_1_2_13_95_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0655"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00223"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176997"},{"key":"e_1_2_13_98_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911505"},{"key":"e_1_2_13_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.11.009"},{"key":"e_1_2_13_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-020-01679-5"},{"key":"e_1_2_13_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.12.001"},{"key":"e_1_2_13_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2958"},{"key":"e_1_2_13_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.01.018"},{"key":"e_1_2_13_104_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611282113"},{"key":"e_1_2_13_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1571-8"},{"key":"e_1_2_13_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.025"},{"key":"e_1_2_13_107_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00158"},{"key":"e_1_2_13_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(00)00225-8"},{"key":"e_1_2_13_109_2","doi-asserted-by":"publisher","DOI":"10.1039\/b403634d"},{"key":"e_1_2_13_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3542-0_25"},{"key":"e_1_2_13_111_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-2219"},{"key":"e_1_2_13_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230582"},{"key":"e_1_2_13_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4084"},{"key":"e_1_2_13_114_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/690916"},{"key":"e_1_2_13_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.02.035"},{"key":"e_1_2_13_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.046"},{"key":"e_1_2_13_117_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197354"},{"key":"e_1_2_13_118_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612023394043"},{"key":"e_1_2_13_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201148"},{"key":"e_1_2_13_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.06.020"},{"key":"e_1_2_13_121_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4885-10.2011"},{"key":"e_1_2_13_122_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-05-0374"},{"key":"e_1_2_13_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep01837"},{"key":"e_1_2_13_124_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4922-11.2012"},{"key":"e_1_2_13_125_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00457"},{"key":"e_1_2_13_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.32"},{"key":"e_1_2_13_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2013.10.011"},{"key":"e_1_2_13_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105391"},{"key":"e_1_2_13_129_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08084.x"},{"key":"e_1_2_13_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.12.006"},{"key":"e_1_2_13_131_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S88023"},{"key":"e_1_2_13_132_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.983074"},{"key":"e_1_2_13_133_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.5.609"},{"key":"e_1_2_13_134_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-019-0164-y"},{"key":"e_1_2_13_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.037"},{"key":"e_1_2_13_136_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-78207-1_3"},{"key":"e_1_2_13_137_2","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13687"},{"key":"e_1_2_13_138_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026614666141130095855"},{"key":"e_1_2_13_139_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2008.02.003"},{"key":"e_1_2_13_140_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3059-10.2010"},{"key":"e_1_2_13_141_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02375-w"},{"key":"e_1_2_13_142_2","first-page":"408","article-title":"Epothilones: clinical update and future directions","volume":"22","author":"Donovan D.","year":"2008","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_13_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100159"},{"key":"e_1_2_13_144_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2710"},{"key":"e_1_2_13_145_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666170104145640"},{"key":"e_1_2_13_146_2","first-page":"1231","article-title":"Vinca alkaloids","volume":"4","author":"Moudi M.","year":"2013","journal-title":"International Journal of Preventive Medicine"},{"key":"e_1_2_13_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.06.044"},{"key":"e_1_2_13_148_2","first-page":"269","article-title":"Pharmacokinetics and metabolism of vinca alkaloids","volume":"17","author":"Rahmani R.","year":"1993","journal-title":"Cancer Surveys"},{"key":"e_1_2_13_149_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199200444-00002"},{"key":"e_1_2_13_150_2","doi-asserted-by":"publisher","DOI":"10.4037\/ccn1997.17.4.71"},{"key":"e_1_2_13_151_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180123110042"},{"key":"e_1_2_13_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(96)00693-4"},{"key":"e_1_2_13_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2012.09.002"},{"key":"e_1_2_13_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.03.006"},{"key":"e_1_2_13_155_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.495348"},{"key":"e_1_2_13_156_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22487"},{"key":"e_1_2_13_157_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00773"},{"key":"e_1_2_13_158_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00372G"},{"key":"e_1_2_13_159_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx7002195"},{"key":"e_1_2_13_160_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22753"},{"key":"e_1_2_13_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.008"},{"key":"e_1_2_13_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00515-5"},{"key":"e_1_2_13_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.02.035"},{"key":"e_1_2_13_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.10.044"},{"key":"e_1_2_13_165_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13585"},{"key":"e_1_2_13_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.026"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1623181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1623181.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/1623181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:44:08Z","timestamp":1748911448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/1623181"}},"subtitle":[],"editor":[{"given":"Amadou","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":166,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/1623181"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1623181","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1623181"}}