{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:09:49Z","timestamp":1791850189720,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2022,12,22]]},"abstract":"<jats:p>Background. Artemisinin-based Combination Therapies (ACTs) are widely used in the treatment of uncomplicated malaria. Plasmodium falciparum infection is often accompanied by disturbances of hematological and biochemical parameters. The objective of this study was to evaluate the changes in biochemical and hematological parameters during uncomplicated malaria in patients treated with ACTs. Methods. Data from patient with uncomplicated Plasmodium falciparum malaria were pooled from different open-randomized trial evaluating the efficacy of Artesunate-Mefloquine (ASMQ), Artesunate-Amodiaquine (ASAQ), Artemether-Lumefantrine (AL), and Dihydro-artemisinin-Piperaquine (DHAPQ) combinations. Biochemical (transaminases, creatinine, and bilirubin) and hematological (hemoglobin and platelet levels) parameters were performed at baseline (D0) and at day 7 after treatment (D7). Data were analyzed as both continuous and categorical variables with 95% confidence interval. Risks and trends were calculated using multivariate logistic random effect models. Results. A total of 720 patients with completed biological data were included in the analysis (320 in the AL arm, 160 in the ASMQ arm, 120 in the DHAPQ arm, and 88 in the ASAQ arm). The mean age of the patients was <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>9.43<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>9.1<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> years. Male subjects represented 58.47% (sex ratio was 1.4 for males). The mean hemoglobin level at inclusion (D0) was 9.79\u2009g\/dl and anemia (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>Hb<\/c:mtext>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>11<\/c:mn>\n                        <c:mtext>\u2009<\/c:mtext>\n                        <c:mtext>g<\/c:mtext>\n                        <c:mo>\/<\/c:mo>\n                        <c:mtext>dl<\/c:mtext>\n                     <\/c:math>\n                  <\/jats:inline-formula>) was 71.43% (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>aOR<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>1.16<\/e:mn>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mfenced open=\"[\" close=\"]\">\n                           <e:mrow>\n                              <e:mn>0.68<\/e:mn>\n                              <e:mo>\u2212<\/e:mo>\n                              <e:mn>1.98<\/e:mn>\n                           <\/e:mrow>\n                        <\/e:mfenced>\n                     <\/e:math>\n                  <\/jats:inline-formula>\n                  <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.57<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). At D7, hemoglobin level was 9.63\u2009g\/dl and anemia was significantly more frequent (78.29% [<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.002<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>]). The mean platelet count at day 0 was 154075.5 platelets\/mm3 of blood and 339328.7 platelets\/mm3 at day 7. Thrombocytopenia was about 53.61% and was associated with malaria (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <m:mtext>aOR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>3.4<\/m:mn>\n                        <m:mtext>\u2009<\/m:mtext>\n                        <m:mfenced open=\"[\" close=\"]\">\n                           <m:mrow>\n                              <m:mn>2.18<\/m:mn>\n                              <m:mo>\u2212<\/m:mo>\n                              <m:mn>5.3<\/m:mn>\n                           <\/m:mrow>\n                        <\/m:mfenced>\n                     <\/m:math>\n                  <\/jats:inline-formula>\n                  <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>&lt;<\/q:mo>\n                        <q:msup>\n                           <q:mrow>\n                              <q:mn>10<\/q:mn>\n                           <\/q:mrow>\n                           <q:mrow>\n                              <q:mo>\u2212<\/q:mo>\n                              <q:mn>3<\/q:mn>\n                           <\/q:mrow>\n                        <\/q:msup>\n                     <\/q:math>\n                  <\/jats:inline-formula>). 19.58% of patients had abnormal ALT and 40.28% had abnormal AST at D0. 27.22% of patients had normal bilirubin at D0. Renal function was normal in all patients in the study. Normalization of transaminases was noted between D0 and D7. The percentage of subjects with normal bilirubin increased between D0 and D7. Renal function did not vary significantly between D0 and D7. Conclusion. Results from this analysis showed that subjects with high parasitaemia had a greater risk of anemia and thrombocytopenia. Artemisinin combinations were well-tolerated as no major biological disturbances were noted. The effects of ACTs on hematologic and biochemical parameters were not different.<\/jats:p>","DOI":"10.1155\/2022\/1635791","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T16:05:09Z","timestamp":1671725109000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Anemia, Thrombocytopenia, and Changes in Biochemical Parameters Occurring in Patients with Uncomplicated Plasmodium falciparum Malaria: Data Analysis from Antimalarial Efficacy-Randomized Trials in Dakar and Kaolack Regions, Senegal"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-6997","authenticated-orcid":true,"given":"Khadime","family":"Sylla","sequence":"first","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Tine","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doudou","family":"Sow","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souleye","family":"Lelo","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Abiola","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"NDiaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magatte","family":"NDiaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuaku","family":"Folly","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on Amath","family":"NDiaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumar","family":"Gaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babacar","family":"Faye","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Cheikh Anta DIOP de Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","DOI":"10.30875\/6c551ba0-en","volume-title":"World Malaria Report 2021","author":"World Health Organization","year":"2021"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.70.8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.614"},{"key":"4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1590\/S0074-02762011000900007","article-title":"Thrombocytopenia in malaria: who cares?","volume":"106","author":"M. 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Nnodim","year":"2010","journal-title":"Journal of Medical Laboratory Science"},{"key":"26","doi-asserted-by":"crossref","DOI":"10.4269\/ajtmh.2007.77.181","article-title":"Artemisinin-based combination treatment of falciparum malaria","volume-title":"Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives: Supplement to Volume 77 (6) of American Journal of Tropical Medicine and Hygiene","author":"F. Nosten","year":"2007"},{"issue":"3","key":"27","first-page":"56","article-title":"A study to evaluate alterations in liver function tests in uncomplicated malaria","volume":"8","author":"C. S. Devi","year":"2018","journal-title":"American Journal of Biochemistry"}],"container-title":["Journal of Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpr\/2022\/1635791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpr\/2022\/1635791.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpr\/2022\/1635791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T16:05:20Z","timestamp":1671725120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jpr\/2022\/1635791\/"}},"subtitle":[],"editor":[{"given":"Jos\u00e9 F.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":27,"alternative-id":["1635791","1635791"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1635791","relation":{},"ISSN":["2090-0031","2090-0023"],"issn-type":[{"value":"2090-0031","type":"electronic"},{"value":"2090-0023","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,22]]}}}