{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:02:21Z","timestamp":1767168141495,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,3,11]]},"abstract":"<jats:p>\n                    Background. Rose acne is a chronic inflammatory skin disease that can cause paroxysmal flushing, persistent erythema, papules or papules on the face, and pustules, and it has a greater impact on the life of patients, so it is important to treat it. Objective. To investigate the effect of Danzhi Xiaoyao Powder combined with photodynamic therapy (PDT) on the curative effect evaluation and prognosis of patients with rose acne. Patients and Methods. The clinical data of 110 rose acne patients who were treated in our hospital from January 2019 to January 2021 were selected as the subject of this retrospective study. They were divided into a control group and a treatment group according to the random residue grouping method. The new crown epidemic, loss to follow-up, etc. fell out of 5 cases in each group, and finally, 50 cases in each group were left. Among them, the control group was treated with PDT, and the treatment group was combined with Danzhi Xiaoyao Powder on the basis of the control group. Then we observe and compare the effects of skin lesion scores and clinical symptom scores and differences in clinical efficacy between the two groups. Results. The comparison of the clinical symptom scores of the two groups of patients before treatment was not statistically significant (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), while the burning score, tingling score, dryness score, and pruritus score of the treatment group after treatment were significantly different. The internal comparison after treatment was lower than before treatment, and the comparison between the treatment groups was significantly higher than the control group, which was statistically significant (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). There was no statistically significant difference in the skin lesion scores of the two groups before treatment (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ), while the papules score, pustule score, erythema score, and telangiectasia score of the treatment group after treatment were significantly different and compared within the group. After treatment, the treatment group was significantly higher than the control group, and the comparison was statistically significant (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). The effective rate of 98.00% in the treatment group was significantly higher than the 76.00% in the control group, and the difference was statistically significant (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). The clinical efficacy of the two groups of patients showed that the rash, chest tightness, nausea, and diarrhea of the treatment group were significantly lower than those of the control group, and the difference was statistically significant (\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. Danzhi Xiaoyao Powder combined with PDT to treat rose acne is effective, can quickly control inflammatory papules and inflammatory erythema, effectively improve the clinical symptoms of patients, and reduce adverse reactions.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1636839","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T18:35:28Z","timestamp":1647023728000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Therapeutic Effect and Prognosis of Danzhi Xiaoyao Powder Combined with Photodynamic Therapy in the Treatment of Rose Acne"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xinjian","family":"Yu","sequence":"first","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Dermatological Department, Attending Psychiatrist, 430061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Dermatological Department, Supervising Technician, 430061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Dermatological Department, Attending Psychiatrist, 430061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwen","family":"Yin","sequence":"additional","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Dermatological Department, Attending Psychiatrist, 430061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1674-5627","authenticated-orcid":true,"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Dermatological Department, Attending Psychiatrist, 430061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1214234"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12814"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.049"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/32488"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2019.07.003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027318"},{"key":"7","volume-title":"Standards for the Pharmaceutical Industry of the People\u2019s Republic of China M","author":"State Medical Administration","year":"1992"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"issue":"13","key":"9","first-page":"2","article-title":"Tacrolimus combine with recombinant bovine basic fibroblast growth factor treat hormone dependence dermatitis","volume":"13","author":"C. 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