{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:46:35Z","timestamp":1747190795023,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2022,6,3]]},"abstract":"<jats:p>Adult-onset Still\u2019s disease (AOSD) is an inflammatory disorder characterized by fever, arthritis, and a transient skin rash. It is a rare condition characterized by inflammatory multisystem changes of unknown cause. A 35-year-old woman was admitted to rheumatology department of tertiary care hospital complaining of painful wrist and skin rash as well as fever, generalized lymphadenopathy, weight loss, and fatigue. The early diagnosis of AOSD was confirmed by clinical history, examination, and laboratory tests, as well as a confirmatory skin biopsy with typical histopathological features, namely, upper epidermal dyskeratosis and dermal inflammatory neutrophilic infiltration. The patient\u2019s condition was treated with steroids and NSAIDs, to which she responded well, and on follow-up, her symptoms regressed along with improvement in biochemical parameters. The authors suggest that skin biopsy and confirmation of histopathological diagnosis of AOSD are useful in the diagnosis and proper management of AOSD patients in cases with clinical suspicion of AOSD.<\/jats:p>","DOI":"10.1155\/2022\/1653683","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T16:50:13Z","timestamp":1654275013000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Adult-Onset Still\u2019s Disease with Dermatopathic Lymphadenitis Clinicopathologic Features: A Rare Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2022","author":[{"given":"Reda A.","family":"Elhawary","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"},{"name":"Department of Pathology, Histopathology Consultant, Khamis Mushyte General Hospital, Khamis Mushait, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-418X","authenticated-orcid":true,"given":"Mir","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Khalid University and Associated Hospital, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed S.","family":"Abdelwahed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"},{"name":"Department of Pathology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Somaily","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatology Division, King Khalid University Medical City, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahenda Y.","family":"Alemam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatology Division, Khamis Mushyte General Hospital, Khamis Mushait, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1136\/ard.60.1.4"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1080\/03009740510026616"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.jaut.2018.07.018"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1093\/ageing\/afl128"},{"key":"5","first-page":"424","article-title":"Preliminary criteria for classification of adult still\u2019s disease","volume":"19","author":"M. 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