{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:20:26Z","timestamp":1767165626786,"version":"build-2238731810"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["(2019) 4008"],"award-info":[{"award-number":["(2019) 4008"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["gyfynsfc [2020]-39"],"award-info":[{"award-number":["gyfynsfc [2020]-39"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Increasing studies have identified the function of sirtuin\u20101 (SIRT1) in ocular diseases. Hence, this study is aimed at exploring the potential role of SIRT1 in choroidal neovascularization\u2010 (CNV\u2010) induced age\u2010related macular degeneration (AMD) development and the associated mechanism. Expression of SIRT1\/SOX9\/LCN2 in the hypoxic cells was determined, and their interactions were predicted by bioinformatics websites and followed by the verification by luciferase assay and chromatin immunoprecipitation (ChIP). Their\n                    <jats:italic>in vitro<\/jats:italic>\n                    effects on hypoxic cells concerning cell viability, apoptosis, migration, and angiogenesis were detected through gain\u2010 and loss\u2010of\u2010function assays. Besides, their\n                    <jats:italic>in vivo<\/jats:italic>\n                    effect was explored using the established CNV mouse models. Highly expressed LCN2, SOX9, and SIRT1 were observed in hypoxic cells. LCN2 was increased by SOX9 and SIRT1 deacetylated SOX9 to promote its nuclear translocation, which further inhibited the viability of human retinal pigment epithelial cells and promoted cell apoptosis and angiogenesis as well as CNV\u2010induced AMD formation. The relieving role of LCN2 inhibition on CNV\u2010induced AMD without toxicity for mice was also demonstrated by\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments. Overall, SIRT1 promoted the formation of CNV\u2010induced AMD through SOX9 deacetylation\u2010caused LCN2 upregulation, representing a promising target for CNV\u2010induced AMD management.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1671438","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T19:51:00Z","timestamp":1654804260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[Retracted] Sirtuin 1 Induces Choroidal Neovascularization and Triggers Age\u2010Related Macular Degeneration by Promoting LCN2 through SOX9 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