{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:04:00Z","timestamp":1789585440861,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2022,6,23]]},"abstract":"<jats:p>We present the case of a 24-year-old male, who received a minor ABO-incompatible allogeneic hematopoietic stem cell transplant (HSCT, blood group O+ \u27f6 A+) from an HLA-matched unrelated female donor, as consolidation therapy for relapsed precursor-B-cell acute lymphoblastic leukemia. The donor had a known history of Hashimoto\u2019s thyroiditis before HSCT. At day +10 posttransplant, the patient developed severe hemolysis, which required emergent red blood cell exchange. Additionally, about a year posttransplant, he had circulating antithyroglobulin antibodies, decreased free-T4 (fT4) and increased serum thyroid-stimulating hormone (TSH). The potential causes of the posttransplant hemolytic episode and hypothyroidism are discussed. While the hemolysis was worsened by the transfusion of A red blood cells (RBCs) in the context of passenger lymphocyte syndrome, the thyroid dysfunction might be explained by an autoimmune disease transferred from the donor. The case highlights the possibility of several non-relapse-related complications of HSCT occurring in the same patient. It is critical that such adverse outcomes are distinguished from classical graft-versus-host disease (GVHD) for adequate recipient counseling, posttransplant screening, and prompt treatment.<\/jats:p>","DOI":"10.1155\/2022\/1690489","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T23:20:12Z","timestamp":1656026412000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Passenger Lymphocyte Syndrome and Autoimmune Hypothyroidism Following Hematopoietic Stem Cell Transplantation"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-345X","authenticated-orcid":true,"given":"Denis F.","family":"Noubouossie","sequence":"first","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed I. A.","family":"Zaanona","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, O\u2019Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano J.","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, O\u2019Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy P.","family":"Pham","sequence":"additional","affiliation":[{"name":"Be The Match Seattle Collection Center, National Marrow Donor Program, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-7856","authenticated-orcid":true,"given":"Marisa B.","family":"Marques","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Stasi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, O\u2019Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0516-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.05.011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05572-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2017.05.009"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.33.7212"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39080824.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02587.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v87.2.843.bloodjournal872843"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.79"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-1366-shdtpl"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/bf02743271"},{"key":"12","first-page":"357","article-title":"Autoimmune thyroiditis after bone marrow transplantation","volume":"5","author":"D. 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