{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:55:13Z","timestamp":1790657713368,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,8]]},"abstract":"<jats:p>Purpose. To assess the efficacy of neoadjuvant chemotherapy plus limb-sparing surgery for osteosarcoma and its impact on long-term quality of life. Methods. Between August 2016 and December 2018, 90 patients with osteosarcoma treated in Nanchong Central Hospital were recruited and divided at a ratio of 1\u2009:\u20091 to receive limb-sparing surgery (control group) or limb-sparing surgery plus neoadjuvant chemotherapy (study group) by random number table methods. The clinical endpoints were clinical efficacy and long-term quality of life. Results. Limb-sparing surgery plus neoadjuvant chemotherapy was associated with a significantly higher efficacy versus limb-sparing surgery alone. Limb-sparing surgery plus neoadjuvant chemotherapy resulted in a significantly higher Enneking score and a higher good function rating of patients versus limb-sparing surgery. The two groups showed a high but similar 1-year survival rate. Patients given limb-sparing surgery plus neoadjuvant chemotherapy showed significantly higher 2-year and 3-year survival and a longer mean survival versus those receiving limb-sparing surgery alone. Limb-sparing surgery plus neoadjuvant chemotherapy resulted in significantly higher scores of role emotional, mental health, physical function, and social function and a lower bodily pain score than limb-sparing surgery alone. Limb-sparing surgery plus neoadjuvant chemotherapy was associated with significantly lower fatigue, nausea and vomiting, dyspnea, constipation, and diarrhea scores and a significantly higher health status score versus monotherapy of limb-sparing surgery. Conclusion. Neoadjuvant chemotherapy plus limb-sparing surgery improves the postoperative limb function and long-term quality of life of patients with osteosarcoma, which shows great potential for clinical promotion.<\/jats:p>","DOI":"10.1155\/2022\/1693824","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T10:35:31Z","timestamp":1660041331000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of Neoadjuvant Chemotherapy plus Limb-Sparing Surgery for Osteosarcoma and Its Impact on Long-Term Quality of Life"],"prefix":"10.1155","volume":"2022","author":[{"given":"Shixia","family":"Jing","sequence":"first","affiliation":[{"name":"Central Sterile Supply Department, Nanchong Central Hospital, Nanchong 637000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Rizhao Central Hospital, Rizhao 276800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nanchong Central Hospital, Nanchong 637000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Rizhao Central Hospital, Rizhao 276800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-4844","authenticated-orcid":true,"given":"Qiang","family":"He","sequence":"additional","affiliation":[{"name":"The Affifiliated Nanhua Hospital, Department of Hand Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq276"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3838"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.024"},{"issue":"4","key":"4","first-page":"690","article-title":"Multidisciplinary approach to osteosarcoma","volume":"82","author":"A. 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