{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:08:29Z","timestamp":1784297309131,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":103,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201800005"],"award-info":[{"award-number":["HHSN268201800005"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011531","name":"University of Alabama","doi-asserted-by":"publisher","award":["HHSN268201800007I"],"award-info":[{"award-number":["HHSN268201800007I"]}],"id":[{"id":"10.13039\/100011531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","award":["HHSN268201800003I"],"award-info":[{"award-number":["HHSN268201800003I"]}],"id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["HHSN268201800006I"],"award-info":[{"award-number":["HHSN268201800006I"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007241","name":"Kaiser Foundation Research Institute","doi-asserted-by":"publisher","award":["HHSN268201800004I"],"award-info":[{"award-number":["HHSN268201800004I"]}],"id":[{"id":"10.13039\/100007241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR001424"],"award-info":[{"award-number":["KL2 TR001424"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL098445"],"award-info":[{"award-number":["R01 HL098445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . We evaluated the association of apolipoprotein B (apoB) with low\u2010density lipoprotein cholesterol (LDL\u2010C), non\u2010high\u2010density lipoprotein cholesterol (non\u2010HDL\u2010C), and triglycerides (TG) in early adulthood with concordant\/discordant associations and midlife NAFLD.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Participants from the CARDIA study were included (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092,655; baseline mean age: 25.0, 59.1% female, and 48.6% black). NAFLD was defined as liver attenuation \u226440 Hounsfield units after excluding other causes of liver fat. Logistic regression models assessed the odds of Y25 NAFLD among tertiles of apoB, LDL\u2010C, non\u2010HDL\u2010C, and TG and quartiles of the apoB\/TG ratio. Discordance\/concordance analyses examined the association of apoB with each lipid marker and Y25 NAFLD.\n                    <jats:italic>Results<\/jats:italic>\n                    . The Y25 NAFLD prevalence was 10%. The high\u2010tertile TG group (OR 1.87, 95% CI, and 1.30\u20132.69) and the low\u2010 (OR 1.98, 95% CI, and 1.30\u20133.01) and middle\u2010apoB\/TG ratio groups (OR 1.78, 95% CI, and 1.17\u20132.72) had the greatest odds of midlife NAFLD. Using discordance\/concordance analysis, the high\u2010apoB\/high\u2010TG group had the highest odds of NAFLD (OR 1.69, 95% CI, and 1.09\u20132.61) followed by the low\u2010apoB\/high\u2010TG group. The high apoB\/low TG group had the lowest odds of NAFLD.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Among the studied lipid markers in early adulthood, TG levels have the strongest and most consistent association with midlife NAFLD.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1727711","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T16:05:22Z","timestamp":1649952322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study"],"prefix":"10.1155","volume":"2022","author":[{"given":"Sahil","family":"Khanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norrina B.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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