{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:45:44Z","timestamp":1790937944094,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Brain SPECT with <jats:sup>99m<\/jats:sup>Tc\u2010TRODAT\u20101 (SPECT\u2010TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. <jats:italic>Objective<\/jats:italic>. To compare results of SPECT\u2010TRODAT with clinical findings in patients with Parkinsonism. <jats:italic>Methods<\/jats:italic>. We evaluated 153 outpatients. SPECT\u2010TRODAT results were visually analyzed into normal, abnormal, symmetric, and asymmetric, and according to the degree of impairment into mild, moderate, marked, and severe (1\u20134). <jats:italic>Results<\/jats:italic>. A direct relationship was found between motor scores severity (MDS\u2010UPDRS\u2010III) and SPECT\u2010TRODAT\u2010reduced binding in general, in the group of patients with synucleinopathies (rho\u2009=\u20090.258, <jats:italic>p<\/jats:italic> = 0.005), especially in patients with Parkinson\u2019s disease (rho\u2009=\u20090.204, <jats:italic>p<\/jats:italic> = 0.049). Changes in SPECT\u2010TRODAT had high correspondence with symmetry in all Parkinsonism. When comparing groups to the correspondence predominantly bilateral or unilateral impairment in SPECT, there was a difference between patients with SNP (<jats:italic>p<\/jats:italic> = 0.041) and between this group and patients with secondary Parkinsonism (SP) (<jats:italic>p<\/jats:italic> &lt; 0.0001). It was handy in differentiating drug\u2010induced Parkinsonism from synucleinopathies. In the group of drug\u2010induced Parkinsonism, younger people were the ones who showed the most significant reductions in radiotracer uptake. In this group, nonmotor signs resulted in examinations with more significant reductions in radiotracer uptake. When the scans without alterations and those that did not correspond to the symmetry were considered negative, SPECT\u2010TRODAT\u2019s accuracy and specificity to differentiate PD from other forms of Parkinsonism were low. There was an inverse correlation between the severity of the SPECT\u2010TRODAT result and the absence of nonmotor signs in patients with drug\u2010induced Parkinsonism. <jats:italic>Conclusion<\/jats:italic>. The authors concluded that the SPECT with 99mTc\u2010TRODAT\u20101 was mainly useful in differentiating between synucleinopathies and secondary Parkinsonism.<\/jats:p>","DOI":"10.1155\/2022\/1746540","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T13:35:29Z","timestamp":1646746529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Brain SPECT with <sup>99m<\/sup>Tc\u2010TRODAT\u20101 in the Differential Diagnosis of Parkinsonism"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-2687","authenticated-orcid":false,"given":"Giorgio","family":"Fabiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-0347","authenticated-orcid":false,"given":"Carlos Henrique Ferreira","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-2372","authenticated-orcid":false,"given":"Raul Martins","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-3386","authenticated-orcid":false,"given":"Gabriel Sampaio","family":"Froehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-1073","authenticated-orcid":false,"given":"H\u00e9lio Afonso Ghizoni","family":"Teive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/jpd-181474"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.03.003"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.4018\/978-1-5225-5282-6.ch013"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.601225"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20720"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.037"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20112"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21479"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000002461"},{"key":"e_1_2_8_14_2","unstructured":"PitellaF. 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