{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:21Z","timestamp":1787017701529,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":310,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2017612"],"award-info":[{"award-number":["BE2017612"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["H2019091"],"award-info":[{"award-number":["H2019091"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . This study aimed to assess the efficacy of dual\u2010tracer [\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTA\u2010somatostatin receptor analogs (SSAs) and\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010fluorodeoxyglucose (FDG)] positron emission tomography\/computed tomography (PET\/CT) imaging for detecting bone metastases (BMs) in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP\u2010NENs).\n                    <jats:italic>Methods<\/jats:italic>\n                    . We retrospectively enrolled 74 GEP\u2010NEN patients with BMs from two centers, who underwent dual\u2010tracer PET\/CT from January 2014 to March 2021. We compared and analyzed effectiveness of the dual PET\/CT imaging techniques on the BMs, based on\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG and\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTA\u2010SSAs. Specifically, we analyzed the imaging results using\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    tests for classification variables, paired\u2010sample tests for number of BMs, Wilcoxon\u2019s signed rank test for number of lesions, and the Kruskal\u2013Wallis test for standard uptake value (SUV) ratio comparison. The correlation of dual\u2010tracer SUVmax with Ki\u201067 index was analyzed by Spearman\u2019s correlation coefficient.\n                    <jats:italic>Results<\/jats:italic>\n                    . The detection efficiencies of dual\u2010tracer PET\/CT imaging in patients with different pathologies showed discordant for detecting liver metastases and BMs in group neuroendocrine tumor (NET) G3,\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTA\u2010SSAs was better at detecting BMs for NET G3 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.049 for SUV\n                    <jats:sub>T\/B<\/jats:sub>\n                    and\n                    <jats:italic>P<\/jats:italic>\n                    = 0.026 for the number of metastatic lesions). In addition, statistical significance was found among osteogenesis group, osteolysis group, and the no\u2010change group (for bone SUV\n                    <jats:sub>T\/B<\/jats:sub>\n                    value detected by\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG and Ki\u201067 index, osteogenesis group &lt; osteolysis group; for bone SUV\n                    <jats:sub>T\/B<\/jats:sub>\n                    detected by\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTA\u2010SSAs, osteogenesis group &gt; the no\u2010change group). What is more, liver and bone SUVmax and Ki\u201067 index were positively correlated in\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG imaging (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001 for liver;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002 for bone), and negatively correlated in\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTA\u2010SSAs imaging (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001 for liver;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.039 for bone).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    .\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTA\u2010SSAs was superior to\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG for detecting BMs in NET G1\/G2 (well and moderately differentiated NETs), as well as in NET G3 (poorly differentiated NETs). Relatively good differentiation was observed in the osteogenesis group. In addition, dual\u2010tracer PET\/CT imaging results were observably correlated with tumor differentiation.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1750132","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T05:05:09Z","timestamp":1667883909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Detection of Bone Metastases by\n                    <sup>68<\/sup>\n                    Ga\u2010DOTA\u2010SSAs and\n                    <sup>18<\/sup>\n                    F\u2010FDG PET\/CT: A Two\u2010Center Head\u2010to\u2010Head Study of Gastroenteropancreatic Neuroendocrine Neoplasms"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-0157","authenticated-orcid":false,"given":"Rui","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-8500","authenticated-orcid":false,"given":"Qing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-2056","authenticated-orcid":false,"given":"Fei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-1218","authenticated-orcid":false,"given":"Changzhi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-2870","authenticated-orcid":false,"given":"Xiaochen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-3379","authenticated-orcid":false,"given":"Shiming","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-0715","authenticated-orcid":false,"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-246X","authenticated-orcid":false,"given":"Pengjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-6933","authenticated-orcid":false,"given":"Guoqiang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2084-5193","authenticated-orcid":false,"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-3095","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-3080","authenticated-orcid":false,"given":"Jiangyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_12_1_2","first-page":"817","article-title":"Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. 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