{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:12:27Z","timestamp":1759936347009,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Datsing Bio-Tech Co. Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the role of porcine small intestinal submucosa (SIS) in reducing fistula during urethroplasty and to observe its degradation process in beagle models. <jats:italic>Methods<\/jats:italic>. 22 male beagles were divided into the SIS group and control group. All animals received surgical operation to establish the hypospadias model. Urethroplasty was followed. In the SIS group, the urethra was covered with a single\u2010layer SIS material while no SIS material covered in the control group. At the 2<jats:sup>nd<\/jats:sup>, 4<jats:sup>th<\/jats:sup>, and 12<jats:sup>th<\/jats:sup> weeks after the operation, there were 3, 3, and 5 animals in each group, respectively, sacrificed for surgical site histological examinations. The inflammation reaction and collagen hyperplasia levels were assessed. The fistula was identified by retrograde cystourethrography at the 4<jats:sup>th<\/jats:sup> and 12<jats:sup>th<\/jats:sup> weeks after the operation. <jats:italic>Results<\/jats:italic>. the incidence of urethral fistula was 25% (2\/8) in the SIS group and 75% (6\/8) in the control group. The inflammation reaction of SIS and control groups had no significant difference (<jats:italic>U<\/jats:italic> = 52.50, <jats:italic>P<\/jats:italic> = 0.58). The collagen fiber increased in both groups; however, the SIS group had a much more gentle increase compared to the control group (<jats:italic>U<\/jats:italic> = \u22120.00, <jats:italic>P<\/jats:italic> &lt; 0.001). In the SIS group, the SIS material was roughly complete on the specimens 2\u2009w after surgery but became loose and discontinuous 4\u2009w after surgery and could not be found 12\u2009w after surgery. <jats:italic>Conclusion<\/jats:italic>. The material can decrease the incidence of urethral fistula in the animal models, when used as a coverage layer. The SIS degradation process started 2\u2009w\u20134\u2009w after the operation and finished before 12\u2009w in the animal model.<\/jats:p>","DOI":"10.1155\/2022\/1755886","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T03:20:05Z","timestamp":1664335205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Using of Single\u2010Layer Porcine Small Intestinal Submucosa in Urethroplasty on a Beagle Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-6724","authenticated-orcid":false,"given":"Daorui","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5751-7516","authenticated-orcid":false,"given":"Yunman","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.04.043"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2019.03.004"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03008-x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2013.09.003"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.17219\/pim\/68618"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0165-3"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.037"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13208"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856201753395798"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200106150-00024"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(00)00017-4"},{"key":"e_1_2_10_12_2","first-page":"1282","article-title":"Biocompatibility of porcine small intestinal submucosa and rat endothelial progenitor cells in vitro","volume":"8","author":"Rong J. 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