{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:36:06Z","timestamp":1781537766449,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":186,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>While sevoflurane and desflurane have been regarded as inhalation agents providing rapid induction and emergence, previous studies demonstrated the superiority of desflurane\u2010anesthesia compared to sevoflurane\u2010anesthesia in the postoperative recovery in obese and geriatric patients. We investigated whether a short\u2010term switch of sevoflurane to desflurane at the end of sevoflurane\u2010anesthesia enhances patient postoperative recovery profile in non\u2010obese patients. We randomly divide patients undergoing elective surgery (n\u2009=\u200960) into two groups: sevoflurane\u2010anesthesia group (Group\u2010S, <jats:italic>n<\/jats:italic> = 30) and sevoflurane\u2010desflurane group (Group\u2010SD, <jats:italic>n<\/jats:italic> = 30). In Group\u2010S, patients received only sevoflurane\u2010anesthesia until the end of surgery (for &gt;2 hours). In Group\u2010SD, sevoflurane was stopped and switched to desflurane\u2010anesthesia before the completion of sevoflurane\u2010anesthesia (for approximately 30 minutes). We assessed the intergroup differences in the times to get eye\u2010opening, extubation, and a bispectral index of 80 (BIS\u201080). Group\u2010SD showed significantly shorter times to get eye\u2010opening (438 \u00b1 101 vs. 295 \u00b1 45\u2009s; mean difference, 143\u2009s; 95% confidence interval [CI], 101\u2013183; <jats:italic>p<\/jats:italic> &lt; 0.001), extubation (476 \u00b1 108 vs. 312 \u00b1 42\u2009s; mean difference, 164\u2009s; 95% CI, 116\u2013220; <jats:italic>p<\/jats:italic> &lt; 0.001), and BIS\u201080 (378 \u00b1 124 vs. 265 \u00b1 49 minutes; mean difference, 113\u2009s; 95% CI, 58\u2013168 <jats:italic>p<\/jats:italic> &lt; 0.001) compared to Group\u2010S. There was no between\u2010group difference in postoperative nausea, vomiting, and hypoxia incidences. Our results suggested that the short\u2010term (approximately 30 minutes) switch of sevoflurane to desflurane at the end of sevoflurane\u2010anesthesia can facilitate the speed of postoperative patient recovery.<\/jats:p>","DOI":"10.1155\/2022\/1812728","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T05:50:05Z","timestamp":1657173005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effects of Switching from Sevoflurane to Short\u2010Term Desflurane prior to the End of General Anesthesia on Patient Emergence and Recovery: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ji Wook","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Yup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si 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