{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:47:51Z","timestamp":1747190871237,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:p>Merkel cell carcinoma (MCC) is a rare, rapidly growing, and aggressive dermatological neoplasm. It is commonly reported in Caucasian ethnicities, and almost 50% of the patients have a concomitant malignancy and are on immunosuppressive chemotherapy. Here, we present a 79-year-old woman with a history of relapsed Stage II, grade III follicular lymphoma, receiving maintenance rituximab infusions. She presented with a raised erythematous papule on her left cheek. An excisional biopsy of the lesion confirmed a diagnosis of Merkel cell carcinoma. After which, she underwent a wider excision with 1-2\u2009cm margins. PET scan did not reveal any FDG-avid uptake lesions that would be concerning for metastatic disease. However, she underwent a sentinel lymph node biopsy which was also negative. Thus, the diagnosis was finalized as Stage I (T1\u2009N0\u2009M0) MCC. There are only two reported cases in literature about the significant progression of Merkel cell carcinoma in patients who coincidentally were receiving rituximab as a part of treatment for another disease. This raises questions for future investigation and research on whether there is a direct association between rituximab use specifically and the rapid growth of MCC.<\/jats:p>","DOI":"10.1155\/2022\/1814338","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T19:20:06Z","timestamp":1667503206000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Development of Merkel Cell Carcinoma in a Patient Receiving Rituximab"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7544-7649","authenticated-orcid":true,"given":"Bana","family":"Antonios","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ujjwal","family":"Karki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kais","family":"Antonios","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Joseph Mercy Hospital, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-0139","authenticated-orcid":true,"given":"Bipin","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Muhsin","family":"Chisti","sequence":"additional","affiliation":[{"name":"Department of Hematology & Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.028"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5266-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq308"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/983421"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30475"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0103-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01600.x"},{"issue":"2","key":"8","first-page":"180","article-title":"Rapid growth of Merkel cell carcinoma after treatment with rituximab","volume":"5","author":"M. L. Wirges","year":"2006","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0895"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-0288-z"},{"volume-title":"National Comprehensive Cancer Network. Merkel Cell Carcinoma","year":"2022","key":"11"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2022\/1814338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2022\/1814338.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2022\/1814338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T19:20:12Z","timestamp":1667503212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crionm\/2022\/1814338\/"}},"subtitle":[],"editor":[{"given":"Ossama W.","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":11,"alternative-id":["1814338","1814338"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1814338","relation":{},"ISSN":["2090-6714","2090-6706"],"issn-type":[{"type":"electronic","value":"2090-6714"},{"type":"print","value":"2090-6706"}],"subject":[],"published":{"date-parts":[[2022,11,3]]}}}