{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:40Z","timestamp":1787017780002,"version":"build-2736575974"},"reference-count":110,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173406"],"award-info":[{"award-number":["82173406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition.<\/jats:p>","DOI":"10.1155\/2022\/1821780","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T17:21:53Z","timestamp":1647278513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Research Progress on Targeted Antioxidant Therapy and Vitiligo"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jingzhan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-2314","authenticated-orcid":false,"given":"Xiaojing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13198"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00242.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.048"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12949"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30609-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-00329-y"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.031"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.09.003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15743"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2841814"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14792"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126570"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.20455\/ros.2016.803"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.151935"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13145"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2976"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.3126\/kumj.v12i2.13660"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.65"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791526105"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12103"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400633"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12372"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5693572"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2020.1835952"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2223-0"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.9926"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.12.013"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.152"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.56"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13895"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0396-2"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12664"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01207.x"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14393"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.03.007"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.10.003"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.09.004"},{"key":"e_1_2_7_40_2","first-page":"449","article-title":"Cinnamaldehyde protects against oxidative stress and inhibits the TNF-\u03b1-induced inflammatory response in human umbilical vein endothelial cells","volume":"46","author":"Kim N. Y.","year":"2020","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.07.012"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.10.421"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12462"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.06.015"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.01.020"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15330"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-3168-4"},{"key":"e_1_2_7_48_2","first-page":"799","article-title":"Decreased proinflammatory cytokine production by peripheral blood mononuclear cells from vitiligo patients following aspirin treatment","volume":"26","author":"Zailaie M. Z.","year":"2005","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12812"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12203"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.02.027"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13350"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00337.x"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.10.010"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21344"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.07.010"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.5.1001"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00421.2009"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5107"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13409"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2019.03.002"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.06.010"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122077"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1543-z"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1531"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14738"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21426"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.04.167"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.235"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.10050"},{"key":"e_1_2_7_71_2","first-page":"2657","article-title":"Screening and analysis of differentially expressed genes of human melanocytes in skin cells mixed culture","volume":"11","author":"Mei X.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.25"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.372"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.335"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.026096"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2018.0154"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180011"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.06.003"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1125-0"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24596"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102698"},{"key":"e_1_2_7_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12241"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0126-4"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.03.1165"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13954"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.09.001"},{"key":"e_1_2_7_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00762.x"},{"key":"e_1_2_7_88_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-201897"},{"key":"e_1_2_7_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep13542"},{"key":"e_1_2_7_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.001"},{"key":"e_1_2_7_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.004"},{"key":"e_1_2_7_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0297-3"},{"key":"e_1_2_7_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23102600"},{"key":"e_1_2_7_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22081303"},{"key":"e_1_2_7_95_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700026200"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12855"},{"key":"e_1_2_7_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.08.007"},{"key":"e_1_2_7_98_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13612"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.03.054"},{"key":"e_1_2_7_100_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100596"},{"key":"e_1_2_7_101_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9827519"},{"key":"e_1_2_7_102_2","first-page":"9","article-title":"Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways","volume":"22","author":"Song X.","year":"2008","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_7_103_2","first-page":"3727","article-title":"A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells","volume":"41","author":"Yin L.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_7_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.04.015"},{"key":"e_1_2_7_105_2","first-page":"2665","article-title":"Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd","volume":"42","author":"Mamat N.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_7_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104416"},{"key":"e_1_2_7_107_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6675657"},{"key":"e_1_2_7_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.03.009"},{"key":"e_1_2_7_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.03.007"},{"key":"e_1_2_7_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmv040"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1821780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1821780.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/1821780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T21:11:48Z","timestamp":1748898708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/1821780"}},"subtitle":[],"editor":[{"given":"Chengfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":110,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/1821780"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1821780","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1821780"}}