{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:20:27Z","timestamp":1767165627076,"version":"build-2238731810"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"\n Objective. To explore and analyze the efficacy of methylprednisolone combined with azithromycin in the treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP) and its effect on the changes of T lymphocyte subsets. Methods. A total of 120 children with RMPP admitted to our hospital from September 2016 to September 2020 were randomized at a ratio of 1\u2009:\u20091 into the control group (conventional treatment) and the observation group (methylprednisolone plus conventional treatment). Outcome measures included clinical efficacy, symptoms mitigation, changes in inflammatory factors, T lymphocyte subsets, and adverse reactions. Results. Compared with the control group, the total clinical effective rate of the observation group was higher (\n \n \n P<\/a:mi>\n <<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>\n ). The disappearance time of cough, wheezing, pulmonary rales, and X-ray lung shadows in the observation group was significantly shorter than that in the control group after treatment (\n \n \n P<\/c:mi>\n <<\/c:mo>\n 0.05<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>\n ). The serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-\u03b1), and interleukin (IL)-8 levels of the observation group after treatment were significantly lower than those of the control group (\n \n \n P<\/e:mi>\n <<\/e:mo>\n 0.05<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>\n ). Compared with the control group, the observation group had a higher CD4+ value, lower CD8+ value, and higher CD4+\/CD8+ value after treatment (all\n \n \n P<\/g:mi>\n <<\/g:mo>\n 0.05<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>\n ). There was no significant difference in adverse reactions between the two groups during treatment (\n \n \n P<\/i:mi>\n ><\/i:mo>\n 0.05<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>\n ). Conclusion. Methylprednisolone plus azithromycin might serve as an alternative in the treatment of RMPP. It facilitates the mitigation of clinical symptoms and signs and regulates the level of inflammatory factors and cellular immune dysfunction, with good effectiveness and a high safety profile.\n <\/jats:p>","DOI":"10.1155\/2022\/1833195","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T15:05:05Z","timestamp":1650985505000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Methylprednisolone plus Azithromycin in the Treatment of RMPP and Its Effect on the Changes of T Lymphocyte Subsets"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jun","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-7838","authenticated-orcid":true,"given":"Fei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"297","article-title":"Effect evaluation and clinical analysis of ambroterol oral liquid Jubei mixture in the treatment of children with bronchopneumonia","volume":"19","author":"Y. Zhang","year":"2019","journal-title":"Chinese Medicine and Clinical"},{"issue":"3","key":"2","first-page":"585","article-title":"The application value of C-reactive protein, respiratory pathogen antibodies combined with white blood cell count in the diagnosis of early childhood pneumonia","volume":"34","author":"Y. Yin","year":"2019","journal-title":"China Maternal and Child Health"},{"issue":"16","key":"3","first-page":"1211","article-title":"Epidemiological characteristics of Mycoplasma pneumoniae infection among hospitalized children in Beijing during the past 10 years","volume":"34","author":"C. Yan","year":"2019","journal-title":"Chinese Journal of Practical Pediatrics"},{"issue":"1","key":"4","first-page":"76","article-title":"Efficacy and safety evaluation of compound glycyrrhizin combined with azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia","volume":"39","author":"A. Shuang","year":"2019","journal-title":"Chinese Journal of Hospital Pharmacy"},{"issue":"4","key":"5","first-page":"584","article-title":"Effect of different treatment timings of fiberoptic bronchoalveolar lavage on the therapeutic effect of refractory Mycoplasma pneumoniae pneumonia","volume":"28","author":"J. Yu","year":"2017","journal-title":"Hainan Medicine"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268818000778"},{"issue":"1","key":"7","first-page":"491","article-title":"Observation on the curative effect of antibiotic de-escalation in the treatment of severe pneumonia in children","volume":"28","author":"G. Mei","year":"2017","journal-title":"China Maternal and Child Health Research"},{"issue":"16","key":"8","first-page":"2102","article-title":"Efficacy of methylprednisolone combined with azithromycin in the treatment of refractory mycoplasma pneumonia and its influence on inflammatory indexes in children","volume":"31","author":"H. Hou","year":"2020","journal-title":"Hainan Medicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518820412"},{"issue":"15","key":"10","first-page":"89","article-title":"Effects of budesonide aerosol inhalation combined with methylprednisolone on cytokine expression and immune function of T lymphocyte subsets in children with mycoplasma pneumonia","volume":"44","author":"S. Hou","year":"2017","journal-title":"Chinese Journal of Practical Medicine"},{"issue":"1","key":"11","first-page":"337","article-title":"Efficacy analysis of roxithromycin and azithromycin dry suspension in children with pneumonia caused by mycoplasma infection","volume":"28","author":"Y. He","year":"2017","journal-title":"China Maternal and Child Health Research"},{"issue":"4","key":"12","first-page":"26","article-title":"Effect and safety of gamma globulin combined with glucocorticoid pulse therapy in the treatment of serum CRP in children with refractory mycoplasma pneumonia","volume":"42","author":"Z. Zhu","year":"2017","journal-title":"Chinese Journal of Biochemical Medicine"},{"issue":"10","key":"13","first-page":"1115","article-title":"The effect of budesonide combined with terbutaline atomization inhalation on children with mycoplasma pneumonia and its effect on lung function","volume":"46","author":"H. Chen","year":"2018","journal-title":"Modern Medicine"},{"issue":"7","key":"14","first-page":"48","article-title":"Clinical efficacy of Yanhuning injection in adjuvant treatment of children with refractory Mycoplasma pneumoniae pneumonia and its effects on immune function and cytokines","volume":"25","author":"Z. Tan","year":"2017","journal-title":"Journal of Practical Cardiovascular and Cerebrovascular Diseases"},{"issue":"19","key":"15","first-page":"168","article-title":"Efficacy analysis of glucocorticoids in the treatment of children with refractory Mycoplasma pneumoniae pneumonia","volume":"15","author":"G. Meng","year":"2017","journal-title":"Chinese Medicine Guide"}],"updated-by":[{"DOI":"10.1155\/2023\/9898404","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"record-id":"59374"},{"DOI":"10.1155\/2023\/9898404","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/1833195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/1833195.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/1833195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T15:05:20Z","timestamp":1650985520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/1833195\/"}},"subtitle":[],"editor":[{"given":"Zhaoqi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":15,"alternative-id":["1833195","1833195"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1833195","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,26]]}}}