{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:45:29Z","timestamp":1747190729914,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nanshan District Science and Technology Research Program","award":["NS2021129"],"award-info":[{"award-number":["NS2021129"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,10,13]]},"abstract":"<jats:p>Objective. To investigate the feasibility and correlation of sacroiliac joint (SIJ) fat fraction (FF) and R2<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msup>\n                           <a:mrow\/>\n                           <a:mrow>\n                              <a:mo>\u2217<\/a:mo>\n                           <\/a:mrow>\n                        <\/a:msup>\n                     <\/a:math>\n                  <\/jats:inline-formula> as markers of bone metabolism in patients with ankylosing spondylitis (AS). Methods. 75 AS patients were classified into an early active group (EA), late active group (LA), and inactive group (IA). Additionally, 54 matched healthy individuals were selected to be part of the normal control group (NC). All participants underwent chemical shift encoded based MRI (IDEAL-IQ) and routine clinical SIJ MRI at 3.0\u2009T. FF and R2<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:msup>\n                           <c:mrow\/>\n                           <c:mrow>\n                              <c:mo>\u2217<\/c:mo>\n                           <\/c:mrow>\n                        <\/c:msup>\n                     <\/c:math>\n                  <\/jats:inline-formula> were measured in subchondral bone, bone marrow edema (BME), and fat metaplasia (FM). Out of the participants, 39 with BME lesions (15 from EA, 16 from LA, 8 from IA) and 39 with FM lesions (9 from EA, 17 from LA, 13 from IA) were included. Differences in FF, R2<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:msup>\n                           <e:mrow\/>\n                           <e:mrow>\n                              <e:mo>\u2217<\/e:mo>\n                           <\/e:mrow>\n                        <\/e:msup>\n                     <\/e:math>\n                  <\/jats:inline-formula> value for subchondral bone of all participants and for BME, FM lesions were evaluated. Subsequently, different stages of BME and FM in patient groups were compared, and the relationship between FF and R2<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:msup>\n                           <g:mrow\/>\n                           <g:mrow>\n                              <g:mo>\u2217<\/g:mo>\n                           <\/g:mrow>\n                        <\/g:msup>\n                     <\/g:math>\n                  <\/jats:inline-formula> was analyzed. Results. A significant difference in FF was demonstrated among the BME, FM and the normal bone marrow (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), meanwhile, the difference of R2<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:msup>\n                           <k:mrow\/>\n                           <k:mrow>\n                              <k:mo>\u2217<\/k:mo>\n                           <\/k:mrow>\n                        <\/k:msup>\n                     <\/k:math>\n                  <\/jats:inline-formula> value in FM was significantly lower (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>p<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.034<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, 0.012) than that of BME and that of normal bone marrow. At lever of different lesions, only the FF for BME was significantly different among 3 patient groups (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.001<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>), while there was no significantly different FF for FM among 3 patient groups. Unlike in BME lesions, the FF in FM lesions had a negative correlation with R2<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:msup>\n                           <q:mrow\/>\n                           <q:mrow>\n                              <q:mo>\u2217<\/q:mo>\n                           <\/q:mrow>\n                        <\/q:msup>\n                     <\/q:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>&lt;<\/s:mo>\n                        <s:mn>0.001<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>r<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mo>\u2212<\/u:mo>\n                        <u:mn>0.488<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>). Conclusion. FF and R2<jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:msup>\n                           <w:mrow\/>\n                           <w:mrow>\n                              <w:mo>\u2217<\/w:mo>\n                           <\/w:mrow>\n                        <\/w:msup>\n                     <\/w:math>\n                  <\/jats:inline-formula> measurements help to quantitatively analyze the bone marrow fat composition and bony trabecular microstructure changes in AS, providing a noninvasive and accurate assessment basis for AS bone metabolism abnormalities.<\/jats:p>","DOI":"10.1155\/2022\/1846667","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T03:05:08Z","timestamp":1665716708000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["Chemical Shift-Encoded MRI of Bone Metabolic Markers in Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-133X","authenticated-orcid":true,"given":"Li-ping","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui-yun","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-1096","authenticated-orcid":true,"given":"Long","family":"Qian","sequence":"additional","affiliation":[{"name":"MR Research, GE Healthcare, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-2873","authenticated-orcid":true,"given":"Zhi-bin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001787"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04930-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180050"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2950-7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100259"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520931281"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.3.7644622"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170344"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215589"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13485"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4321-x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2017.10.015"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050645"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001799"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27634"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26729"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa564"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex514"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1510877"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170079"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214983"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2019.1704053"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/1846667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/1846667.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/1846667.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T03:05:12Z","timestamp":1665716712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/1846667\/"}},"subtitle":[],"editor":[{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":24,"alternative-id":["1846667","1846667"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1846667","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"type":"electronic","value":"1875-8630"},{"type":"print","value":"0278-0240"}],"subject":[],"published":{"date-parts":[[2022,10,13]]}}}