{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:53:24Z","timestamp":1788360804196,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    . Augmented renal clearance (ARC), which is commonly defined as increased renal clearance above 130\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    , is a common phenomenon among critically ill patients. The increased elimination rate of drugs through the kidneys in patients with ARC can increase the risk of treatment failure due to the exposure to subtherapeutic serum concentrations of medications and affect the optimal management of infections, length of hospital stay, and outcomes. The main goal of this review article is to summarize the recommendations for appropriate dosing of antibiotics in patients with ARC.\n                    <jats:italic>Methods<\/jats:italic>\n                    . This article is a narrative review of the articles that evaluated different dosing regimens of antibiotics in patients with ARC. The keywords \u201cAugmented Renal Clearance,\u201d \u201cCritically ill patients,\u201d \u201cDrug dosing,\u201d \u201cSerum concentration,\u201d \u201cBeta\u2010lactams,\u201d \u201cMeropenem,\u201d \u201cImipenem,\u201d \u201cGlycopeptide,\u201d \u201cVancomycin,\u201d \u201cTeicoplanin,\u201d \u201cLinezolid,\u201d \u201cColistin,\u201d \u201cAminoglycosides,\u201d \u201cAmikacin,\u201d \u201cGentamycin,\u201d \u201cFluoroquinolones,\u201d \u201cCiprofloxacin,\u201d and \u201cLevofloxacin\u201d were searched in Scopus, Medline, PubMed, and Google Scholar databases, and pediatric, nonhuman, and non\u2010English studies were excluded.\n                    <jats:italic>Results<\/jats:italic>\n                    . PK properties of antibiotics including lipophilicity or hydrophilicity, protein binding, the volume of distribution, and elimination rate that affect drug concentration should be considered along with PD parameters for drug dosing in critically ill patients with ARC.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . This review recommends a dosing protocol for some antibiotics to help the appropriate dosing of antibiotics in ARC and decrease the risk of subtherapeutic exposure that may be observed while receiving conventional dosing regimens in critically ill patients with ARC.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1867674","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T06:53:31Z","timestamp":1644389611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Are Antibiotics Appropriately Dosed in Critically Ill Patients with Augmented Renal Clearance? 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