{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:03:26Z","timestamp":1770908606011,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2019AAC03227"],"award-info":[{"award-number":["2019AAC03227"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Bionics and Biomechanics"],"published-print":{"date-parts":[[2022,9,29]]},"abstract":"<jats:p>Objective. Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that is essential to numerous physiological and pathological processes. VEGF also contributes to embryo implantation by promoting embryo development, enhancing endometrial receptivity (ER), and promoting interactions between the endometrium and developing embryo. Changes in VEGF expression are linked to repeated implantation failure (RIF). Control endometrial tissues demonstrated an increase in VEGF expression during the implant window period, which promoted early villous vascularization and embryo implantation. The purpose of this study is to investigate the relationship between RIF and the expression of ER markers, such as VEGF during the implantation window stage. Methods. The Yinchuan Maternal and Child Health Hospital collected 192 cases of FET endometrial tissues in the implantation window stage between January 2019 and December 2021. Immunohistochemistry was utilized to measure the levels of VEGF expression in patients with RIF (RIF group, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>82<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and patients with a successful pregnancy (control group, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>110<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The relationship between VEGF and the RIF group was analyzed using Spearman\u2019s correlation coefficient. Results. VEGF levels were significantly lower during the implantation window stage (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Conclusion. VEGF was expressed in planting window stage. The decrease of VEGF during the implantation window was correlated with RIF.<\/jats:p>","DOI":"10.1155\/2022\/1937714","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T21:50:08Z","timestamp":1664488208000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between Endometrial Vascular Endothelial Growth Factor Expression and Pregnancy Outcome of Frozen\u2013Thawed Embryo Transfer in Patients with Repeated Implantation Failure"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-9440","authenticated-orcid":true,"given":"Rui","family":"Jin","sequence":"first","affiliation":[{"name":"Medical Center, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenye","family":"Ma","sequence":"additional","affiliation":[{"name":"Medical Center, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Tang","sequence":"additional","affiliation":[{"name":"Medical Center, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Center, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Bai","sequence":"additional","affiliation":[{"name":"Medical Center, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Reng","sequence":"additional","affiliation":[{"name":"Medical Center, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0414-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.613277"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-056714"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/2096-2924.296549"},{"issue":"4","key":"5","first-page":"925","article-title":"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14","volume":"8","author":"D. Maglione","year":"1993","journal-title":"Oncogene"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020253"},{"issue":"10","key":"7","first-page":"19","article-title":"Jia Yuan Yuan endometrial receptivity markers and repeated implant failure of I VF-ET correlation study","volume":"19","author":"Q. Menglong","year":"2019","journal-title":"Prescription Drugs in China"},{"issue":"5","key":"8","first-page":"7","article-title":"Definition and influencing factors of repeated planting failure","volume":"34","author":"Q. Song","year":"2018","journal-title":"Journal of Practical Obstetrics and Gynecology"},{"issue":"7","key":"9","first-page":"12","article-title":"Correlation study of endometrial receptivity markers and repeated implant failure","volume":"11","author":"N. ichao","year":"2019","journal-title":"Family Planning and Obstetrics and Gynecology in China"},{"issue":"10","key":"10","first-page":"1508","article-title":"Effect of high-dose application of integrin v 3 antagonist on mother and fetus in mice","volume":"19","author":"L. Guiju","year":"2012","journal-title":"Chinese Basic Medicine"},{"issue":"14","key":"11","first-page":"1655","article-title":"Effect of endometrial curettage on pregnancy outcomes of implantation-related factors and of patients with repeated implantation failure","volume":"18","author":"Y. 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Wang","year":"2010","journal-title":"Journal of Reproductive Immunology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2012.01116.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu213"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12266"}],"updated-by":[{"DOI":"10.1155\/2023\/9895160","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"record-id":"50598"},{"DOI":"10.1155\/2023\/9895160","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000}}],"container-title":["Applied Bionics and Biomechanics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/abb\/2022\/1937714.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/abb\/2022\/1937714.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/abb\/2022\/1937714.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T21:50:24Z","timestamp":1664488224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/abb\/2022\/1937714\/"}},"subtitle":[],"editor":[{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":17,"alternative-id":["1937714","1937714"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1937714","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9895160","asserted-by":"object"}]},"ISSN":["1754-2103","1176-2322"],"issn-type":[{"value":"1754-2103","type":"electronic"},{"value":"1176-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}