{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:20:17Z","timestamp":1783682417286,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:p>Objective. To investigate the effects of ultrasound-guided fascia iliac compartment block (FICB) on patients\u2019 postoperative pain and inflammatory factors as well as nucleotide-binding domain and leucine-rich repeat (NLR) family, pyrin domain-containing 3 (NLRP3) in femoral intertrochanteric fracture. Methods. This single-blind randomized controlled study included 231 patients with femoral intertrochanteric fracture treated in our hospital from January 2017 to December 2020. All patients were randomized into two groups, the FICB group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>116<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and the general anesthesia group (control group, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>115<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The serum NLRP3 levels and inflammatory factors were evaluated. The heart rate (HR), mean arterial pressure (MAP), and SpO2 values were recorded. Pain condition was measured by the visual analogue scale (VAS) score. Harris score was performed for positive hip function. Results. The values of HR and MAP were significantly lower after anesthesia induction in FICB groups compared with the control group. However, no significant difference was found for SpO2. Compared with the control group, the VAS scores within 72\u2009h after surgery were all markedly lower in the FICB group than in the control group and showed no significant difference at 1 week after surgery. The levels of NLRP3 and interleukin 6 (IL-6) were significantly lower in FICB patients at 1\u2009h, 6\u2009h, 24\u2009h, 48\u2009h, and 72\u2009h after surgery compared with the control group. Tumor necrosis factor-\u03b1 (TNF-\u03b1) showed a significant lower level in the FICB group at 1\u2009h and 6\u2009h after surgery, and significant lower levels of C-reactive protein (CRP) were found at 1\u2009h and 24\u2009h after surgery compared with the control group. Positive correlation was found between NLRP3 and IL-6, as well as CRP and VAS scores after 1\u2009h of the surgery. No significant difference was found for both Harris score and postoperative complications between the two groups. Conclusion. Fascia iliac compartment block could reduce the postoperative pain, which might be associated with the decrease of the serum levels of NLRP3, CRP, IL-6, and TNF-\u03b1 in femoral intertrochanteric fracture patients.<\/jats:p>","DOI":"10.1155\/2022\/1944659","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T01:20:14Z","timestamp":1652836814000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Ultrasound-Guided Fascia Iliac Compartment Block on Serum NLRP3 and Inflammatory Factors in Patients with Femoral Intertrochanteric Fracture"],"prefix":"10.1155","volume":"2022","author":[{"given":"Kailai","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Lishui Municipal Central Hospital, Lishui, Zhejiang 323000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lishui Municipal Central Hospital, Lishui, Zhejiang 323000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lishui Municipal Central Hospital, Lishui, Zhejiang 323000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-4216","authenticated-orcid":true,"given":"Leiming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lishui Municipal Central Hospital, Lishui, Zhejiang 323000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.04.015"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S150067"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04769-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-019-0398-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.447"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/os.12853"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/os.12579"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-0364.2015.05.011"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/os.12535"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11477"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002019"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2019.03.004"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.03.014"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7917"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/230949901602400109"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000543"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1266-0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-017-0354-y"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1597-y"},{"key":"20","article-title":"Inflammatory markers in postoperative cognitive dysfunction for patients undergoing total hip arthroplasty: a meta-analysis","volume":"1-12","author":"C. Fu","year":"2022","journal-title":"Aging Clinical and Experimental Research"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2019.08.008"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01357-z"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/1944659.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/1944659.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/1944659.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T01:20:18Z","timestamp":1652836818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/1944659\/"}},"subtitle":[],"editor":[{"given":"Leyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":22,"alternative-id":["1944659","1944659"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1944659","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,17]]}}}