{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:05:55Z","timestamp":1783451155011,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,7,30]]},"abstract":"<jats:p>Objective. The study aimed to investigate the correlation of miR-1246 in saliva with periodontal indicators, inflammatory cytokines, and protease molecules in patients with chronic periodontitis. Methods. Thirty-five patients with chronic periodontitis were included as the chronic periodontitis group, and 35 healthy individuals were selected as the healthy control group during the same period. The miR-1246 levels, inflammatory cytokine interleukin (IL)-1\u03b2, IL-6, IL-17, tumor necrosis factor-\u03b1 (TNF-\u03b1), matrix metalloproteinase (MMP-1), MMP-8, and MMP tissue inhibitor (TIMP-1) in saliva were determined, and periodontal indexes, including the plaque index (PLI), bleeding index (BI), periodontal probing depth (PD), and attachment loss (AL) were examined. Results. The salivary levels of miR-1246, IL-1\u03b2, IL-6, IL-17, TNF-\u03b1, MMP-1, MMP-8, and TIMP-1 and the periodontal indexes PLI, GI, PD, and AL in the chronic periodontitis group were significantly higher than those in the healthy control (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Salivary levels of miR-1246 in patients with chronic periodontitis were positively correlated with the levels of IL-1\u03b2, IL-6, IL-17, TNF-\u03b1, MMP-1, MMP-8, TIMP-1, PLI, GI, PD, and AL (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusion. Abnormally elevated levels of miR-1246 in saliva of patients with chronic periodontitis correlate with levels of periodontal indices, inflammatory cytokines, and protease molecules.<\/jats:p>","DOI":"10.1155\/2022\/1949159","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T20:20:30Z","timestamp":1659212430000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Correlation Analysis of miR-1246 Expression in Saliva of Patients with Chronic Periodontitis and Periodontal Indexes, Inflammatory Cytokines, and Protease Molecules"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-5227","authenticated-orcid":true,"given":"Shuainan","family":"Wu","sequence":"first","affiliation":[{"name":"Stomatology Clinic of Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobao","family":"Li","sequence":"additional","affiliation":[{"name":"Stomatology Clinic of Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Stomatology Clinic of Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Stomatology Clinic of Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pang","sequence":"additional","affiliation":[{"name":"Stomatology Clinic of Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026620666200110161105"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200114114802"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2069410"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/1574888x12666170718161740"},{"issue":"3","key":"5","first-page":"330","article-title":"[Functions of non-coding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells]","volume":"38","author":"J. 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