{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:42:18Z","timestamp":1756384938799,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>This study is aimed at exploring the value of magnetic resonance diffusion\u2010weighted imaging (DWI) combined with perfusion\u2010weighted imaging (PWI) for diagnosing melanoma under a three\u2010dimensional (3D) hybrid segmentation algorithm. 40 patients with melanoma were collected as research objects and subjected to magnetic resonance imaging (MRI) examination. A segmentation model was constructed and the original images were input. The noise contained in the images was preprocessed and normalized, and the mixed level set segmentation was performed after linear fusion of the images. Imaging findings were analyzed to find that the combined diagnosis of DWI and PWI with a 3D hybrid segmentation algorithm had the advantage of being clear and accurate. 10 primary cases were detected, which occurred in the cerebral meninges; 30 cases of metastases occurred inside the skull, mostly adjacent to the surface of the brain. The typical T1\u2010weighted imaging (T1WI) and T2\u2010weighted imaging (T2WI) of melanoma showed high signal and low signal, respectively, and the enhanced scan showed obvious enhancement. Atypical melanoma was manifested variously in MRI; a few had cystic necrosis, and an enhanced scan of the solid area revealed significant enhancement. Patients with multiple metastatic melanomas mainly showed low signal on DWI, and patients with primary or single metastatic melanoma mainly showed high signal or mixed high signal. Patients with perfusion imaging showed high perfusion on PWI. The 3D hybrid segmentation algorithm helped to improve the accuracy of DWI combined with PWI in the diagnosis of melanoma. This work provided a certain reference for the clinical diagnosis of melanoma.<\/jats:p>","DOI":"10.1155\/2022\/1968189","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T17:35:34Z","timestamp":1656351334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion\u2010Weighted Imaging Combined with Perfusion\u2010Weighted Imaging under Segmentation Algorithm in the Diagnosis of Melanoma"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-1905","authenticated-orcid":false,"given":"Chuankui","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-697X","authenticated-orcid":false,"given":"Peng","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-5668","authenticated-orcid":false,"given":"Yuping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7123-7441","authenticated-orcid":false,"given":"Guobao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0373-6"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-019-0358-y"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14818.Epub.2020.Mar.2"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000521"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014096"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01356-6"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109212"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312612"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000568"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2013.778375.PMID:23570455"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20200825"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1239"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.714318"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-02003-y"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.32604\/cmes.2021.016728"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1206-y"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.future.2020.03.039"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00278.PMID:29438650"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scs.2020.102655"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2016.08.026.Epub.2016.Sep.13"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202279.Epub.2021.Jan.10"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109268"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5539"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4799116.PMID:34354552"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.05.067"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12847"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2018.09.006"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4470-y"}],"container-title":["Contrast Media &amp; 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