{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:13:33Z","timestamp":1740165213744,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2022,11,21]]},"abstract":"<jats:p>Purpose. To describe a case of acute anterior uveitis (AAU) with HLA-B27 positivity following epithelium-off corneal cross-linking (CXL) in a patient with a previous intrastromal corneal ring segment. Observations. A 28-year-old male with keratoconus (KCN) developed ophthalmalgia, perilimbal injection, hypopyon, and decline in corrected distance visual acuity (CDVA) 3 days after CXL. A working diagnosis of inflammatory versus infectious AAU was made, and the patient was treated with topical tobramycin, polymyxin B\/trimethoprim, prednisolone, and oral valacyclovir. Clinical appearance and CDVA improved, ultimately returning to baseline by two weeks postoperatively. Diagnostic laboratory workup revealed HLA-B27 positivity. Conclusions and Importance. A comprehensive laboratory workup is helpful to identify potential causative and associated systemic conditions when encountering AAU after CXL. Given the overlap in patient demographics for KCN and HLA-B27 positivity, clinicians should consider this entity in the differential diagnosis and treatment of such cases.<\/jats:p>","DOI":"10.1155\/2022\/2014549","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T19:20:17Z","timestamp":1669058417000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Acute Anterior Uveitis with HLA-B27 Positivity after Corneal Cross-Linking with Previous Intrastromal Corneal Ring Segment"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-353X","authenticated-orcid":true,"given":"Asher","family":"Khan","sequence":"first","affiliation":[{"name":"Dean McGee Eye Institute, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA"},{"name":"College of Medicine, University of Oklahoma, 800 Stanton L. Young Blvd, Oklahoma City, OK 73117, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-0579","authenticated-orcid":true,"given":"Charles D.","family":"McGuffey","sequence":"additional","affiliation":[{"name":"Dean McGee Eye Institute, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-5705","authenticated-orcid":true,"given":"Andrew T.","family":"Melson","sequence":"additional","affiliation":[{"name":"Dean McGee Eye Institute, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-5025","authenticated-orcid":true,"given":"Kamran M.","family":"Riaz","sequence":"additional","affiliation":[{"name":"Dean McGee Eye Institute, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.04.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd011150.pub2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2010.495117"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2020.09.020"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5005\/jp-journals-10025-1110","article-title":"Anterior uveitis after collagen cross-linking for keratoconus","volume":"4","author":"Y. Goldich","year":"2015","journal-title":"International Journal of Keratoconus and Ectatic Corneal Diseases"},{"volume-title":"HLA B27 Syndromes","year":"2021","author":"P. 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