{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:25Z","timestamp":1792787545035,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2019 Six \u201cOne\u201d Project for High-level Health Talents","award":["LGY2019049"],"award-info":[{"award-number":["LGY2019049"]}]},{"name":"2019 Six \u201cOne\u201d Project for High-level Health Talents","award":["H2019048"],"award-info":[{"award-number":["H2019048"]}]},{"name":"2019 Medical Scientific Research Project of Provincial Health Commission","award":["LGY2019049"],"award-info":[{"award-number":["LGY2019049"]}]},{"name":"2019 Medical Scientific Research Project of Provincial Health Commission","award":["H2019048"],"award-info":[{"award-number":["H2019048"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,5]]},"abstract":"<jats:p>\n                    Breast cancer (BC) ranks first in morbidity and mortality among female malignant tumors worldwide. This study is aimed at clarifying clinical value of contrast-enhanced ultrasound (CEUS) in the diagnosis and differentiation of BC. A total of 108 BC patients admitted to our hospital from January 2019 to December 2021 were enrolled. All patients underwent conventional color Doppler ultrasound and CEUS imaging examination. All ultrasound images were analyzed by a senior (5+ years) sonographer. The lesion location, echo, size, and color Doppler flow imaging (CDFI) blood flow distribution of benign and malignant BC were assessed. The transverse and longitudinal diameters of malignant BC presented significant elevation compared with the control group (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). CEUS is more reliable than conventional ultrasound in the differentiation of benign and malignant breast lesions, and CEUS has the best reliability. The comparison of CEUS observation indicators between benign and malignant groups demonstrated that CEUS enhancement patterns (time and intensity) and morphological features (lesion boundary, shape, range, homogeneity, and filling defect) presented statistical significance (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). Irregular shape and range expansion were high-specificity indicators (all &gt;90.00%); fast-forward, high enhancement, clear boundary, and range expansion were high-sensitivity (all &gt;90.00%); and fast-forward, high enhancement, and clear boundary were low-specificity indicators (all &lt;50.00%); moderate sensitivity is as follows: homogeneous enhancement and range expansion (all &gt;80.00%). The area under curve of CEUS (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mn>0.735<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn>0.053<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ) presented elevation relative to conventional ultrasound (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>0.901<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>0.024<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ), with statistical significance (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>Z<\/i:mi>\n                        <i:mn>1<\/i:mn>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>2.462<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ). Relative to conventional ultrasound, the specificity and positive predictive value of CEUS presented elevation (\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.05<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ). In conclusion, in the differentiation of benign and malignant breast lesions, CEUS has better diagnostic accuracy and reliability than conventional ultrasound. The diagnostic advantages of CEUS are to elevate the diagnostic specificity and positive predictive value and reduce the misdiagnosis rate.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2017026","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T18:05:12Z","timestamp":1662401112000},"page":"1-6","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Value of Contrast-Enhanced Ultrasound in Breast Cancer Diagnosis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yingying","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Ultrasound, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu 223300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-8192","authenticated-orcid":true,"given":"Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu 223300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Surgery of Thyroid Gland and Breast, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu 223300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu 223300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu 223300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu 223300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i2.61"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.8.4063"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0556-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6497"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.06.043"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-014-0566-7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.08.004"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1059"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1039\/c5ib00040h"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.03.005"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016151455"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18650"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/20239.8177"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1177\/0284185118773510"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.03.030"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2018.05.007"},{"issue":"4","key":"17","first-page":"415","article-title":"Contrast-enhanced ultrasonography in diagnosis of benign and malignant breast lesions","volume":"35","author":"X. 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