{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:28:27Z","timestamp":1740148107133,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971262","ZYYC21005","2020YFS0575"],"award-info":[{"award-number":["81971262","ZYYC21005","2020YFS0575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["81971262","ZYYC21005","2020YFS0575"],"award-info":[{"award-number":["81971262","ZYYC21005","2020YFS0575"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["81971262","ZYYC21005","2020YFS0575"],"award-info":[{"award-number":["81971262","ZYYC21005","2020YFS0575"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Intelligence and Neuroscience"],"published-print":{"date-parts":[[2022,1,10]]},"abstract":"<jats:p>Background. Cancer diagnosis entails substantial psychological distress and is associated with dramatically increased risks of suicidal behaviors. However, little is known about the suicide risk among cancer survivors who developed a second malignant neoplasm (SMN). Methods. Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study involving 7,824,709 patients with first malignant neoplasm (FMN). We measured the hazard ratios (HRs) of suicide death after receiving a SMN diagnosis using Cox proportional hazard models, as compared with patients with FMN. The comparison with the US population was achieved by calculating standardized mortality ratios (SMRs). Results. Totally 685,727 FMN patients received a diagnosis of SMN during follow-up, and we in total identified 10,930 and 937 suicide deaths among FMN and SMN patients, respectively. The HR of suicide deaths was 1.23 (95% confidence interval (CI), 1.14\u20131.31) after a SMN diagnosis, compared with FMN patients, after adjusting for sociodemographic factors, tumor characteristics, and cancer treatment. As compared with the general population, while both SMN and FMN patients suffered an increased risk of suicide deaths, the excess risk was higher among SMN patients than FMN patients (age-, sex-, and calendar-year-adjusted SMR 1.65 (95% CI 1.54\u20131.75) vs. 1.29 (95% CI 1.26\u20131.31); <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msub>\n                           <a:mrow>\n                              <a:mi>P<\/a:mi>\n                           <\/a:mrow>\n                           <a:mrow>\n                              <a:mtext>difference<\/a:mtext>\n                           <\/a:mrow>\n                        <\/a:msub>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.0001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Notably, across different time periods, we observed the greatest risk elevation during the first 3 months after a cancer diagnosis. Conclusions. Compared with either patients with FMN or the general population, cancer survivors who received a SMN diagnosis were at increased risk of suicide death. The risk elevation was most prominent soon after the cancer diagnosis, highlighting the necessity of providing timely psychological support to cancer survivors with a SMN.<\/jats:p>","DOI":"10.1155\/2022\/2066133","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T18:21:46Z","timestamp":1641838906000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Increased Risk of Suicide among Cancer Survivors Who Developed a Second Malignant Neoplasm"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4515-1446","authenticated-orcid":true,"given":"Huazhen","family":"Yang","sequence":"first","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Med-X Center for Informatics, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-7671","authenticated-orcid":true,"given":"Yuanyuan","family":"Qu","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Med-X Center for Informatics, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-9959","authenticated-orcid":true,"given":"Yanan","family":"Shang","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Med-X Center for Informatics, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-7059","authenticated-orcid":true,"given":"Chengshi","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Laboratory of Molecular Diagnosis of Cancer, Clinical Research Center for Breast, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-1671","authenticated-orcid":true,"given":"Junren","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Med-X Center for Informatics, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-8661","authenticated-orcid":true,"given":"Donghao","family":"Lu","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Epidemiology, Harvard T. 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Chan School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3845-8079","authenticated-orcid":true,"given":"Huan","family":"Song","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Med-X Center for Informatics, Sichuan University, Chengdu, China"},{"name":"Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjav\u00edk, Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21565"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.366"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31247"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji278"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30164"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1415"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0483"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.485355"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08170-1"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1110307"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31876"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt415"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5373"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26678"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-011-9290-0"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2020.110137"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2020.0046"},{"volume-title":"SEER Cancer Statistics Review. 1975\u20132016","author":"N. 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