{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:47:35Z","timestamp":1747190855617,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anesthesiology Research and Practice"],"published-print":{"date-parts":[[2022,8,25]]},"abstract":"<jats:p>Background. Postoperative nausea and vomiting (PONV) prophylaxis is still inadequate for a significant proportion of women undergoing myomectomy under spinal anesthesia; and it substantially decreases patient\u2019s quality of postoperative recovery. Current protocol and practice favor the use of combination therapy like promethazine\/dexamethasone for PONV prophylaxis with minimal side effects and cost advantages in low-resource climes. Methodology. Seventy American Society of Anesthesiologist (ASA) class I or II women aged 21\u201365 years scheduled for myomectomy were recruited and randomized into group A (promethazine\/dexamethasone group) and group B (ondansetron group). Myomectomy was performed on each patient using spinal anesthesia. After induction of spinal anesthesia, patients in group A received intravenous promethazine 12.5\u2009mg and dexamethasone 8\u2009mg while group B received intravenous ondansetron 8\u2009mg. Early (0\u20133\u2009h) and late (4\u201324\u2009h) PONV was assessed using the numerical scoring scale. Results. Data analysis was done using SPSS version 20. Postoperatively, there was no significant difference in the incidence of early ansd late PONV (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>p<\/a:mi><\/a:math><\/jats:inline-formula>value &gt;0.05) despite the higher incidents in the ondansetron group. The proportion of patients who required rescue antiemetics was more in the ondansetron group when compared with the promethazine\/dexamethasone, with minimal and statistically insignificant side effects in both groups. There was significant patient satisfaction in both groups. Conclusion. The study shows that the combination of low-dose promethazine and dexamethasone is comparable to ondansetron when used as prophylaxis for PONV with cost benefits in low-resource environments.<\/jats:p>","DOI":"10.1155\/2022\/2094662","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T19:20:09Z","timestamp":1661455209000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Low-Dose Promethazine and Dexamethasone against Ondansetron Monotherapy Given as Antiemetic Prophylaxis during Myomectomy Under Spinal Anesthesia: A Randomized Clinical Trial"],"prefix":"10.1155","volume":"2022","author":[{"given":"Emmanuel","family":"Onokpite","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Delta State University Teaching Hospital, Oghara, Delta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-7039","authenticated-orcid":true,"given":"Abiodun Oyinpreye","family":"Jasper","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Delta State University Teaching Hospital, Oghara, Delta, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0721-0495","authenticated-orcid":true,"given":"Philomina Nosa","family":"Edomwonyi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Benin Teaching Hospital, Benin, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199207000-00023"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.134036"},{"issue":"2","key":"3","first-page":"127","article-title":"Postoperative nausea and vomiting. a review: Middle East","volume":"16","author":"S. 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