{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:06:38Z","timestamp":1781834798614,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":150,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Ischemic heart disease (IHD) treatments and preventions by using plant extract and its phytochemical constituents have achieved considerable attention globally due to its cardioprotective effects. This study is aimed at investigating the cardioprotective and vascular effects of <jats:italic>Fumaria indica<\/jats:italic> (<jats:italic>F. indica<\/jats:italic>) crude extract on isoproterenol\u2010 (ISO\u2010) induced myocardial infarction (MI) in Sprague\u2010Dawley (SD) rats. Rats treated with isoproterenol (85\u2009mg\/kg, s.c), administered. Twice at an interval of 24\u2009h showed a significant ST\u2010segment elevation in ECG, edema, and necrosis in histopathology and also in troponin I (cTnI), creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST). Pretreatment with <jats:italic>F. indica<\/jats:italic> (10, 30, and 100\u2009mg\/kg, p.o) for 21 days significantly reversed the effects of isoproterenol\u2010induced ischemic changes in the ECG, levels of cTnI, CPK, LDH, and AST, and histopathological changes. In isolated rat atrial strips, <jats:italic>F. indica<\/jats:italic> induced negative chronotropic and inotropic effects which were not affected by pretreatment with atropine, excluding role of cardiac muscarinic receptors. Cumulative addition of the extract induced a vasorelaxant effect on phenylephrine\u2010evoked contractions in isolated rat aortic rings, which remained unchanged when challenged with <jats:sub>L<\/jats:sub>\u2010NAME, excluding role of endothelial NO. However, extract of <jats:italic>F. indica<\/jats:italic> concentration dependently reversed contractions evoked with high K<jats:sup>+<\/jats:sup>, indicating calcium entry blocking effect. In conclusion, the <jats:italic>F. indica<\/jats:italic> extract is a cardioprotective remedy that ameliorates the isoproterenol\u2010induced cardiotoxic effects and reverses cardiac ischemia, and the calcium antagonistic effect might be of useful in the treatment of MI.<\/jats:p>","DOI":"10.1155\/2022\/2112956","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T04:50:09Z","timestamp":1654059009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cardioprotective Potential of Aqueous Extract of <i>Fumaria indica<\/i> on Isoproterenol\u2010Induced Myocardial Infarction in SD Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-8004","authenticated-orcid":false,"given":"Aimen","family":"Sajid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-9598","authenticated-orcid":false,"given":"Taseer","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-7963","authenticated-orcid":false,"given":"Muhammad","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taous","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6032-3915","authenticated-orcid":false,"given":"Abdul Jabbar","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-3653","authenticated-orcid":false,"given":"Mater H.","family":"Mahnashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8389-8682","authenticated-orcid":false,"given":"Abdulaziz Hassan","family":"Alhasaniah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdullah","family":"Al Awadh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Abdullah","family":"Almazni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Merae","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"249","volume-title":"In: Davidson\u2019s Principle of Practise of Medicine","author":"De Bono D. 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