{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:18:17Z","timestamp":1785388697864,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Science and Technology Innovation Project of Shenyang","award":["RC210266"],"award-info":[{"award-number":["RC210266"]}]},{"name":"Youth Science and Technology Innovation Project of Shenyang","award":["2021-MS-059"],"award-info":[{"award-number":["2021-MS-059"]}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["RC210266"],"award-info":[{"award-number":["RC210266"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2021-MS-059"],"award-info":[{"award-number":["2021-MS-059"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2022,3,20]]},"abstract":"<jats:p>There have been speculation and research linking migraine with abnormalities of platelet aggregation and activation. The role of the P2Y12 platelet inhibitor in the treatment of migraine has not been established. We aim to evaluate the efficacy of the platelet P2Y12 inhibitor in the treatment of migraine and prevention of new-onset migraine headache (MHA) following transcatheter atrial septal defect closure (ASDC). We searched the PubMed, Web of Science, and Cochrane Library databases for relevant studies. The primary outcomes were the headache responder rate and the rate of new-onset migraine attacks following ASDC. Four studies for a total of 262 migraine patients with or without patent foramen ovale (PFO) and three studies involving 539 patients with antiplatelet treatment in the prevention of new-onset migraine following ASDC were included. The pooled responder rate of the P2Y12 inhibitor for migraine was 0.64 (95% CI: 0.43 to 0.81). For patients who underwent ASDC, the use of antiplatelet regimens including the P2Y12 inhibitor, compared with regimens excluding P2Y12 inhibitor, resulted in a lower rate of new-onset migraine (OR: 0.41, 95% CI: 0.22 to 0.77, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.005<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). We concluded that the P2Y12 platelet inhibitor may have a primary prophylactic role in migraine patients with or without PFO and prevent new-onset MHA after ASDC. The responsiveness of the P2Y12 inhibitor could help select candidates who would benefit from PFO closure. It warrants further large-scale research to explore the role of the P2Y12 inhibitor, particularly in a proportion of migraine patients.<\/jats:p>","DOI":"10.1155\/2022\/2118740","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:50:06Z","timestamp":1647813006000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Platelet P2Y12 Inhibitor in the Treatment and Prevention of Migraine: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-5250","authenticated-orcid":true,"given":"Fengzhi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Liaoning Province, People\u2019s Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-7931","authenticated-orcid":true,"given":"Yumeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baoji Central Hospital, Baoji, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-0057","authenticated-orcid":true,"given":"Yanjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, People\u2019s Hospital of Liaoning Province, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-1041","authenticated-orcid":true,"given":"Zhanxiu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Liaoning Province, People\u2019s Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-5205","authenticated-orcid":true,"given":"Fuyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, People\u2019s Hospital of Liaoning Province, People\u2019s Hospital of China Medical University, 33 Wenyi Road, Shenhe District, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5","key":"1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1212\/01.wnl.0000252808.97649.21","article-title":"Migraine prevalence, disease burden, and the need for preventive therapy","volume":"68","author":"R. 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