{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:41:08Z","timestamp":1787665268099,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":203,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA1601040201"],"award-info":[{"award-number":["XDA1601040201"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Intractable aspiration and aspiration pneumonia are complications after radiotherapy for nasopharyngeal carcinoma (NPC), and they may be life\u2010threatening in severe cases. In the past, the efficacy of controlling aspiration and aspiration pneumonia in such patients was not ideal. <jats:italic>Objectives<\/jats:italic>. We aimed to evaluate the effect of tracheoesophageal diversion and laryngotracheal separation (TED\u2010LTS) procedures for these patients. <jats:italic>Material and Methods<\/jats:italic>. We retrospectively analyzed the medical data of five patients with intractable aspiration and recurrent aspiration pneumonia caused by NPC radiotherapy who underwent TED\u2010LTS surgery. The patients were evaluated in terms of aspiration pneumonia control, body weight improvement, removal of tube feeding, oral feeding, and complications. <jats:italic>Results<\/jats:italic>. Intractable aspiration and aspiration pneumonia were completely controlled in all cases, and the patients\u2019 body weight increased from 46.46 \u00b1 4.6 (38.9\u201050.3)\u2009kg to 55.32 \u00b1 2.7 (51.4\u201056.7)\u2009kg. Four patients were able to consume an oral semisolid diet, and one patient maintained an oral liquid diet. Tube feeding was not required in 4 patients. One patient developed postoperative esophageal fistula, which improved after conservative treatment. <jats:italic>Conclusion<\/jats:italic>. TED\u2010LTS is effective for intractable aspiration and aspiration pneumonia caused by NPC radiotherapy and can be used to restore partial oral feeding. However, strict surgical indications should be followed.<\/jats:p>","DOI":"10.1155\/2022\/2162936","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T18:35:07Z","timestamp":1658601307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tracheoesophageal Diversion and Laryngotracheal Separation Procedures for Radiotherapy\u2010Related Intractable Aspiration Pneumonia in Nasopharyngeal Carcinoma"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-3887","authenticated-orcid":false,"given":"Wei","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-7829","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0257-9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-002-0096-x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200007)22:4<393::AID-HED13>3.0.CO;2-2"},{"key":"e_1_2_9_5_2","first-page":"282","article-title":"Assessment and management of dysphagia in patients with nasopharyngeal carcinoma","volume":"21","author":"Marshall J.","year":"1998","journal-title":"Asian Journal of Surgery"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900315"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21627"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23827"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.01.006"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00151-6"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-006-9048-1"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02493482"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947608500507"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000138976"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10668"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20701"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7599.2009.00470.x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10002-3"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.05.018"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.10.002"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/2162936.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/2162936.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/2162936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:22:26Z","timestamp":1735690946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/2162936"}},"subtitle":[],"editor":[{"given":"Samuel","family":"Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/2162936"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2162936","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2162936"}}