{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:21:25Z","timestamp":1784920885868,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HL19C0015"],"award-info":[{"award-number":["HL19C0015"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HL19C0015"],"award-info":[{"award-number":["HL19C0015"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Health Technology R&D Project","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}]},{"name":"Korea Health Technology R&D Project","award":["HL19C0015"],"award-info":[{"award-number":["HL19C0015"]}]},{"name":"Korean Mental Health Technology R&D Project","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}]},{"name":"Korean Mental Health Technology R&D Project","award":["HL19C0015"],"award-info":[{"award-number":["HL19C0015"]}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health, Welfare and Family Affairs","doi-asserted-by":"crossref","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health, Welfare and Family Affairs","doi-asserted-by":"crossref","award":["HL19C0015"],"award-info":[{"award-number":["HL19C0015"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:p>Objectives. Dopamine receptor D2 gene (DRD2) and glucocorticoid receptor gene (NR3C1) are implicated in the development of psychosis. We investigated methylation levels of DRD2 and NR3C1 in peripheral blood of patients with recent-onset (RO) psychosis using bisulfite pyrosequencing as well as its association with childhood trauma and rumination. Methods. In all, 51 individuals with RO psychosis and 47 healthy controls were recruited. DNA methylation levels in the targeted regions of two genes were analyzed and compared. Childhood trauma and rumination were evaluated using the Early Trauma Inventory Self-Report Short Form (ETI-SF) and Brooding Scale (BS), respectively. Correlations between the scores of the ETI-SF and BS and methylation levels were explored. Results. For DRD2, we found no significant differences between groups in terms of methylation level or association with childhood trauma or rumination. For NR3C1, we found a trend level significance for average value of all CpG sites and significant hypermethylation or hypomethylation at specific sites. There was also a significant positive correlation between the methylation level at the CpG8 site of NR3C1 exon 1F and negative symptom subscale score of the PANSS (PANSS-N). Conclusion. Epigenetic alterations of NR3C1 are associated with the pathophysiology of psychosis. Further epigenetic studies will elucidate the molecular mechanisms underpinning the pathophysiology of psychosis.<\/jats:p>","DOI":"10.1155\/2022\/2172564","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T17:20:44Z","timestamp":1659547244000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["DNA Methylation Profiles of the DRD2 and NR3C1 Genes in Patients with Recent-Onset Psychosis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0353-672X","authenticated-orcid":true,"given":"Yan Hong","family":"Piao","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Republic of Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-3963","authenticated-orcid":true,"given":"Yin","family":"Cui","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-5647","authenticated-orcid":true,"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Republic of Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-6082","authenticated-orcid":true,"given":"Kyu Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Nowon Eulji Medical Center, Eulji University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4858-6173","authenticated-orcid":true,"given":"Seung-Hee","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-3709","authenticated-orcid":true,"given":"Seung-Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Inje University Ilsan Paik Hospital, Goyang, Republic of 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