{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:40:03Z","timestamp":1792723203390,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NMUB2019040"],"award-info":[{"award-number":["NMUB2019040"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210982"],"award-info":[{"award-number":["BK20210982"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100719"],"award-info":[{"award-number":["82100719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Emerging evidence suggests that ferroptosis is highly correlated with the pathogenesis of acute kidney injury (AKI). Ferroptosis, an iron\u2010dependent form of cell death, is manifested by a toxic accumulation of lipid peroxides and ultrastructural changes in mitochondria. We herein investigated the effect of Visomitin (SKQ1), a novel mitochondria\u2010targeting antioxidant, on several AKI models <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Our results revealed that SKQ1 treatment greatly reversed renal outcomes in cisplatin, ischemia\u2010reperfusion injury (IRI), or folic acid\u2010induced AKI models. These effects were reflected in attenuated levels of renal injury biomarkers, histologic indices of tubular injury, and inflammatory infiltration in the SKQ1\u2010treated groups. Transcriptomics analysis depicted ferroptosis signaling as the most pronounced pathway downregulated after SKQ1 treatment. Consequently, administration of SKQ1 significantly ameliorated lipid peroxide accumulation and inhibited ferroptosis in the kidneys of mice with AKI. In cultured human proximal tubule epithelial cells (HK2), SKQ1 treatment markedly mitigated cisplatin\u2010induced mitochondrial reactive oxygen species (ROS) production, resulting in lower levels of lipid peroxidation and ferroptosis. In conclusion, SKQ1 treatment protected against ischemic\u2010 or nephrotoxic\u2010induced AKI by inhibiting ferroptosis <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. These results could facilitate a broader understanding of the interaction between mitochondrial antioxidants and ferroptotic defense mechanisms, providing a possible therapeutic strategy in AKI.<\/jats:p>","DOI":"10.1155\/2022\/2223957","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T22:20:08Z","timestamp":1663885208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mitochondrial Targeted Antioxidant SKQ1 Ameliorates Acute Kidney Injury by Inhibiting Ferroptosis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-1373","authenticated-orcid":false,"given":"Jiayu","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9008-4874","authenticated-orcid":false,"given":"Jingyi","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-0815","authenticated-orcid":false,"given":"Juan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4649-2368","authenticated-orcid":false,"given":"Weihua","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-5716","authenticated-orcid":false,"given":"Yunwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.282"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0052-0"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43162-021-00064-x"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201711070"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/japtr.JAPTR_336_18"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.033"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2016.03.002"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3743"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030262"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03362-4"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015121376"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0173-8"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202105043"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2019.151058"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.10.042"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9281519"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100493"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101174"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111749"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1134\/S000629790812002X"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.08.002"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.382"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1266"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040419"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.011"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2082561"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6412682"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2539-4"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24712-6"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJCIIS.IJCIIS_85_18"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2950503"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129903"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018100979"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00441-1"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.039"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29903"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1739447"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.04.013"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1239-1"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.01.182"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00199"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJCIIS.IJCIIS_113_19"},{"key":"e_1_2_11_49_2","article-title":"Rosuvastatin attenuates acute nephrotoxicity through modulation of oxidative stress in Sprague Dawley rats","volume":"69","author":"Rasheed H. A.","year":"2019","journal-title":"The Journal of the Pakistan Medical Association"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113225"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010120"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080843"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-020-01627-z"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR15486.1"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-015-0273-6"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/2223957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/2223957.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/2223957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:28:29Z","timestamp":1748914109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/2223957"}},"subtitle":[],"editor":[{"given":"Liang-Jun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/2223957"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2223957","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2223957"}}