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Zuojin pill (ZJP) is used as the classical prescription for a wide variety of digestive diseases. However, there is a lack of direct evidence for its use in the treatment of chronic nonatrophic gastritis (CNG). In particular, there is a lack of rigorous trials of randomized controlled designs. In this study, a randomized active-controlled clinical trial was performed to verify the efficacy and safety of ZJP in detail. Methods. Patients with CNG were divided into the ZJP group and the Marzulene-S granule group. Patients were enrolled from September 2019 to February 2021 (ChiCTR2000040549). Endoscopy and histology scores were evaluated as the primary outcome measure. The Helicobacter pylori positive rate and the disappearance rate of symptoms were also measured to reflect the outcomes. Finally, adverse events were also calculated as the index of safety. Results. A total of 68 eligible patients were enrolled in this trial and randomly divided into two groups with baseline comparability. ZJP was able to improve the red plaques as well as bile reflux scores compared with Marzulene-S granule (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.043<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.019<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, respectively). Moreover, it also remarkably alleviated the active chronic inflammation score <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <e:mrow>\n                              <e:mi>P<\/e:mi>\n                              <e:mo>=<\/e:mo>\n                              <e:mn>0.043<\/e:mn>\n                           <\/e:mrow>\n                        <\/e:mfenced>\n                     <\/e:math>\n                  <\/jats:inline-formula>. However, there was no difference between the Helicobacter pylori positivity rate <jats:inline-formula>\n                     <j:math xmlns:j=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <j:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <j:mrow>\n                              <j:mi>P<\/j:mi>\n                              <j:mo>=<\/j:mo>\n                              <j:mn>0.752<\/j:mn>\n                           <\/j:mrow>\n                        <\/j:mfenced>\n                     <\/j:math>\n                  <\/jats:inline-formula>. The symptom scores of abdominal distension <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <o:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <o:mrow>\n                              <o:mi>P<\/o:mi>\n                              <o:mo>=<\/o:mo>\n                              <o:mn>0.004<\/o:mn>\n                           <\/o:mrow>\n                        <\/o:mfenced>\n                     <\/o:math>\n                  <\/jats:inline-formula>, belching <jats:inline-formula>\n                     <t:math xmlns:t=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <t:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <t:mrow>\n                              <t:mi>P<\/t:mi>\n                              <t:mo>=<\/t:mo>\n                              <t:mn>0.010<\/t:mn>\n                           <\/t:mrow>\n                        <\/t:mfenced>\n                     <\/t:math>\n                  <\/jats:inline-formula>, and loss of appetite <jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <y:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <y:mrow>\n                              <y:mi>P<\/y:mi>\n                              <y:mo>=<\/y:mo>\n                              <y:mn>0.019<\/y:mn>\n                           <\/y:mrow>\n                        <\/y:mfenced>\n                     <\/y:math>\n                  <\/jats:inline-formula> were alleviated by ZJP, but nausea and vomiting were not <jats:inline-formula>\n                     <db:math xmlns:db=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <db:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <db:mrow>\n                              <db:mi>P<\/db:mi>\n                              <db:mo>=<\/db:mo>\n                              <db:mn>0.616<\/db:mn>\n                           <\/db:mrow>\n                        <\/db:mfenced>\n                     <\/db:math>\n                  <\/jats:inline-formula>. ZJP can also be considered safe with no obvious adverse effects. Conclusion. ZJP might decrease mucosal injury and alleviate symptoms in CNG. In addition, more large-scale clinical trials should be carried out to further confirm its clinical efficacy and safety.<\/jats:p>","DOI":"10.1155\/2022\/2266023","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T22:50:15Z","timestamp":1649371815000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Zuojin Pill for the Treatment of Chronic Nonatrophic Gastritis: A Randomized Active-Controlled Clinical Trial"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ruilin","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[{"name":"Senior Department of Hepatology, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Senior Department of Hepatology, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jing","sequence":"additional","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"He","sequence":"additional","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Cui","sequence":"additional","affiliation":[{"name":"Division of Integrative Medicine, The Fifth Medical Center, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Rong","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-0369","authenticated-orcid":true,"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-7896","authenticated-orcid":true,"given":"Yanling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, General Hospital of PLA, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15352"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040473"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00955-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12498"},{"issue":"4","key":"5","first-page":"177","article-title":"Is traditional Chinese medicine, \u201cradix IlicisPubescentis\u201d possible for treating cardiovascular disease?","volume":"5","author":"S. 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