{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:34:35Z","timestamp":1787974475228,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Indonesian Ministry of Research and Technology National Agency of Research and Innovation","award":["8\/EI\/KPT\/2021"],"award-info":[{"award-number":["8\/EI\/KPT\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2022,3,14]]},"abstract":"<jats:p>Our previous study verified that the waste skin of cocoa (Theobroma cacao L) fruit or waste cocoa pod husks had the efficacy to overcome hair loss or alopecia. This study aims to determine the formula and activity of hair cream of cocoa pod peel water fraction, which is effective in stimulating hair growth. Activity testing uses the modified Tanaka method. The results showed that the cocoa husk wastewater fraction could be formulated into hair cream, but there were changes in viscosity and pH after the freeze-thaw test, but still within the allowed limit. The hair cream water fraction gel stimulated hair growth activity based on the hair length data with a significant difference in concentration of the preparation. The best activity in hair cream preparation was at 12.5% concentration. In addition, there were no signs of irritation to the rabbit\u2019s skin where hair cream preparation was applied. The results of this study indicated that cocoa fruit peel cream can be used for antialopecia treatments.<\/jats:p>","DOI":"10.1155\/2022\/2299725","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T22:51:00Z","timestamp":1647298260000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["New Hair Growth Cream Formulation with Cocoa Pod Peel (Theobroma cacao L.)"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-0236","authenticated-orcid":true,"given":"Resmi","family":"Mustarichie","sequence":"first","affiliation":[{"name":"Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya Nur","family":"Hasanah","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gofarana","family":"Wilar","sequence":"additional","affiliation":[{"name":"Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolih","family":"Gozali","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Technological Pharmacy Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyi Mekar","family":"Saptarini","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Technological Pharmacy Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.22159\/ajpcr.2017.v10i11.21157"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013615"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1159\/000106418"},{"issue":"3","key":"4","first-page":"185","article-title":"Plants used for hair growth promotion: a review","volume":"2","author":"V. 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