{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:05:43Z","timestamp":1787875543680,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703069"],"award-info":[{"award-number":["81703069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700989"],"award-info":[{"award-number":["81700989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020M672523"],"award-info":[{"award-number":["2020M672523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021T140747"],"award-info":[{"award-number":["2021T140747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021JJ31061"],"award-info":[{"award-number":["2021JJ31061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["81703069"],"award-info":[{"award-number":["81703069"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["81700989"],"award-info":[{"award-number":["81700989"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M672523"],"award-info":[{"award-number":["2020M672523"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021T140747"],"award-info":[{"award-number":["2021T140747"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021JJ31061"],"award-info":[{"award-number":["2021JJ31061"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81703069"],"award-info":[{"award-number":["81703069"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81700989"],"award-info":[{"award-number":["81700989"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020M672523"],"award-info":[{"award-number":["2020M672523"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021T140747"],"award-info":[{"award-number":["2021T140747"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ31061"],"award-info":[{"award-number":["2021JJ31061"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:p>Background. Oral submucous fibrosis (OSF) is a potentially malignant disease of the oral cavity. New molecular predictors are needed to identify the high risk of malignant transformation in potentially malignant oral lesions. Our purpose is to explore PTPRZ1 and p120\/<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <a:mi>\u03b2<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>-catenin pathogenesis in the carcinogenesis of OSF to identify novel drug targets. Methods. The expression of PTPRZ1, p120, and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <c:mi>\u03b2<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>-catenin in clinical tissues was detected. Then, PTPRZ1, p120, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <e:mi>\u03b2<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>-catenin, RhoA, Rac1, CDC42, cyclin D1, and c-myc expressions were detected by qRT-PCR and western blot. CCK-8 was applied to measure hOMF cells viability. Wound healing and transwell assay were applied to measure cell migration and invasion. Western blot and IF detected the distribution of p-p120 and p-<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <g:mi>\u03b2<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>-catenin. Tumor formation experiment explored PTPRZ1 effects on OSF. Results. PTPRZ1, p120, and <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <i:mi>\u03b2<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>-catenin were abnormally expressed in cancer tissues. PTPRZ1 regulated the phosphorylation of p120\/<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <k:mi>\u03b2<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula>-catenin. Western blot and IF showed that in the oe-NC group, p-p120 and p-<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <m:mi>\u03b2<\/m:mi>\n                     <\/m:math>\n                  <\/jats:inline-formula>-catenin were expressed in the cell membrane. p-p120 and p-<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <o:mi>\u03b2<\/o:mi>\n                     <\/o:math>\n                  <\/jats:inline-formula>-catenin were expressed in the cytoplasm and nucleus of the oe-PTPRZ1 group. In vitro experimental results revealed overexpression of PTPRZ1 and <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <q:mi>\u03b2<\/q:mi>\n                     <\/q:math>\n                  <\/jats:inline-formula>-catenin, and silencing of p120 promoted cell proliferation, migration, and invasion. The tumor volume and weight in the sh-PTPRZ1 group were significantly reduced. IHC revealed the positive rate of PTPRZ1 was also low. Conclusions. Overexpression of PTPRZ1 regulated the phosphorylation of p120\/<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <s:mi>\u03b2<\/s:mi>\n                     <\/s:math>\n                  <\/jats:inline-formula>-catenin to promote OSF malignancy.<\/jats:p>","DOI":"10.1155\/2022\/2352360","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T23:05:08Z","timestamp":1645657508000},"page":"1-16","source":"Crossref","is-referenced-by-count":5,"title":["Overexpression of PTPRZ1 Regulates p120\/<a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                     <a:mi>\u03b2<\/a:mi>\n                  <\/a:math>-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Liwei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Center of Oral and Maxillofacial Cancer (COMAC), Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Institute of Oral Cancer and Precancerous Lesions, Central South University, Changsha, Hunan Province 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Shen","sequence":"additional","affiliation":[{"name":"Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, Hunan Province 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Institute of Oral Cancer and Precancerous Lesions, Central South University, Changsha, Hunan Province 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-1089","authenticated-orcid":true,"given":"Xing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Center of Oral and Maxillofacial Cancer (COMAC), Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Institute of Oral Cancer and Precancerous Lesions, Central South University, Changsha, Hunan Province 410008, China"},{"name":"Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, Hunan Province 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12924"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.epi-07-2908"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197231"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122940"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-14-99"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02851-w"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(17)32144-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.12.1265"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1693-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-537"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7150\/jca.28231"},{"issue":"2","key":"12","first-page":"198","article-title":"[Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance]","volume":"26","author":"R. Zhu","year":"2017","journal-title":"Shang Hai Kou Qiang Yi Xue"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1077-4"},{"issue":"8","key":"14","first-page":"9042","article-title":"Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-\u03b31 and PIKE are associated with aggressiveness of oral squamous cell carcinoma","volume":"8","author":"Y. Jiang","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.134411"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200516"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.06.001"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80352-9"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2014.15.20.8847"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.016"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.14670\/HH-11-616"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192009"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4181"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.02.008"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.ra119.008742"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.020487997"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002949"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.052"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1258"},{"issue":"12","key":"30","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/hed.23835","article-title":"Protein tyrosine phosphatase receptor R and Z1 expression as independent prognostic indicators in oral squamous cell carcinoma","volume":"37","author":"K. Du\u015b-Szachniewicz","year":"2015","journal-title":"Head & Neck"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29744"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/srep40983"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.12.005"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070741"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1320-12.2012"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0443-x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.017"},{"issue":"34","key":"38","doi-asserted-by":"crossref","first-page":"16872","DOI":"10.1073\/pnas.1902843116","article-title":"p120-catenin regulates WNT signaling and EMT in the mouse embryo","volume":"116","author":"R. Hern\u00e1ndez-Mart\u00ednez","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04022.x"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s211973"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.12.016"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.01067.x"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/2352360.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/2352360.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/2352360.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T23:05:14Z","timestamp":1645657514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2022\/2352360\/"}},"subtitle":[],"editor":[{"given":"Dali","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":42,"alternative-id":["2352360","2352360"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2352360","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"value":"1687-8469","type":"electronic"},{"value":"1687-8450","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,23]]}}}