{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:36:46Z","timestamp":1767339406534,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1I1A3044431"],"award-info":[{"award-number":["NRF-2021R1I1A3044431"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Conventional breeding of wild (<jats:italic>Cucumis melo<\/jats:italic> var. makuwa Makino (CM)) and cultivated (<jats:italic>Cucumis melo<\/jats:italic> var. reticulatus (CR)) melons is aimed at improving their biological traits. Here, we prepared a nontoxic, bioactive extract of vitalmelon (F1 hybrid) and evaluated its antiadipogenic and antiobesity effects in fully differentiated 3T3\u2010L1 adipocytes and high\u2010fat diet\u2010 (HFD\u2010) induced obese C57BL\/6 mice. In fully differentiated 3T3\u2010L1 adipocytes, the vitalmelon extract reduced the DMI\u2010 (dexamethasone, 3\u2010isobutyl\u20101\u2010methylxanthine, and insulin\u2010) induced increases in lipid droplet number and intracellular glucose and triglyceride levels. In addition, the extract inhibited 3T3\u2010L1 preadipocyte differentiation by downregulating <jats:italic>PPAR-\u03b3<\/jats:italic> and target genes <jats:italic>LPL<\/jats:italic>, <jats:italic>CD36<\/jats:italic>, <jats:italic>HMGCR<\/jats:italic>, and <jats:italic>L-FABP<\/jats:italic>. To investigate the inhibitory effects of the vitalmelon extract on lipid metabolism, we measured serum lipid, hormone, and cytokine concentrations; lipolytic activity; lipid accumulation; and adipogenesis in HFD\u2010fed mice treated with the extract. The HFD+vitalmelon\u2010fed mice showed lower blood cholesterol, free fatty acid, sugar, leptin, and insulin concentrations but higher blood adiponectin concentrations than the HFD\u2010fed mice. Moreover, the HFD+vitalmelon\u2010fed mice showed lower abdominal fat levels, smaller fat cells, lower weight, and fewer lipid droplets in the liver tissue than the HFD\u2010fed mice. Therefore, in HFD\u2010fed mice, vitalmelon regulated lipid metabolism through <jats:italic>PPAR-\u03b3<\/jats:italic>, highlighting its potential as a promising antiobesity functional food.<\/jats:p>","DOI":"10.1155\/2022\/2369650","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T05:20:07Z","timestamp":1663910407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Edible Vitalmelon Fruit Extract Inhibits Adipogenesis and Ameliorates High\u2010Fat Diet\u2010Induced Obesity"],"prefix":"10.1155","volume":"2022","author":[{"given":"Lu","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He 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