{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:01:37Z","timestamp":1788184897882,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2022,11,18]]},"abstract":"<jats:p>Aortic dissection is a life-threatening condition caused by a tear in the intimal layer of the aorta or bleeding within the aortic wall, resulting in the separation of the layers of the aortic wall. As Nienaber reported, aortic dissection is most common in people 65\u201375 years old and has an incidence of 35 cases per 100,000 people per year in this population. Many pathogenic factors are involved in aortic dissection, including hypertension, dyslipidemia, and abnormality of the aortic intima caused by genetic variation. However, with the development of gene sequencing and transgenic technology, genetic methods are being used for the diagnosis and treatment of diseases, including acute aortic dissection. Genetic research on acute aortic dissection began around 2006. Recently, research on acute aortic dissection has mainly focused on microRNA (miRNA). Studies have found that miRNA plays a critical regulatory role in the occurrence and development of acute aortic dissection. By regulating miRNA expression, acute aortic dissection can be prevented and treated.<\/jats:p>","DOI":"10.1155\/2022\/2371401","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T20:20:16Z","timestamp":1668802816000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-9523","authenticated-orcid":true,"given":"Ruibin","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Cardiology, Panyu Central Hospital, East Fuyu Road, Qiaonan Street, Panyu District, Guangzhou, China"},{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Affiliated South China Hospital, Southern Medical University (Guangdong Provincial People\u2019s Hospital) Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-327X","authenticated-orcid":true,"given":"Yingqing","family":"Feng","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Affiliated South China Hospital, Southern Medical University (Guangdong Provincial People\u2019s Hospital) Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.668324"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa898"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.11.113"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671-5411.2015.06.013"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.06.019"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35737"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.02.021"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa078"},{"issue":"11","key":"10","first-page":"5138","article-title":"The diagnostic value of microRNA-4787-5p and microRNA-4306 in patients with acute aortic dissection","volume":"9","author":"L. 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