{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:11:56Z","timestamp":1767168716487,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,13]]},"abstract":"<jats:p>\n                    Objective. To investigate the risk factors of acute radiation-induced lung injury (acute RILI) induced by radiotherapy for esophageal cancer. Methods. A total of 206 patients with esophageal cancer who received radiotherapy in our hospital from January 2017 to March 2020 were selected. The general data such as gender, age, and comorbidities of the patients were collected, as well as the levels of cytokines (TNF-\u03b1, TNF-\u03b2, and IL-6) in peripheral blood before radiotherapy; radiotherapy dose-related parameters were recorded during radiotherapy. Follow-up was 12 months after radiotherapy. The patients with induced acute RILI after radiotherapy were set as the observation group (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>75<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). Patients without acute RILI after radiotherapy were set as the control group (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>131<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). Univariate and multivariate logistic regression analysis was performed on the risk factors of acute RILI induced by radiotherapy for esophageal cancer. Results. Univariate analysis and multivariate logistic regression analysis showed that the combined diabetes, total radiation dose, combined lung disease, physical factors (V30, Dmean), and preradiotherapy cytokine (TNF-\u03b1, TNF-\u03b2, and IL-6) elevated level was an independent risk factor for radiotherapy-induced acute RILI in esophageal cancer (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ).Conclusion. Concomitant diabetes, total radiation dose, lung disease, physical factors (V30, Dmean), and levels of cytokines (TNF-\u03b1, TNF-\u03b2, and IL-6) before radiation therapy are risk factors for acute RILI induced by radiation therapy in esophageal cancer. The possibility of acute RILI should be comprehensively assessed according to the patient\u2019s condition, and the radiotherapy regimen should be adjusted to reduce and avoid the induction of acute radiation-induced lung injury.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2416196","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T19:20:05Z","timestamp":1657740005000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors of Acute Radiation-Induced Lung Injury Induced by Radiotherapy for Esophageal Cancer"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7284-1891","authenticated-orcid":true,"given":"Faen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology, The People\u2019s Hospital of Hechi, Guangxi 547000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Oncology, The People\u2019s Hospital of Hechi, Guangxi 547000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oncology, The People\u2019s Hospital of Hechi, Guangxi 547000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The People\u2019s Hospital of Hechi, Guangxi 547000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"22","article-title":"Esophageal cancer","volume":"95","author":"M. 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