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Biological agents used to treat moderate\u2010to\u2010severe plaque psoriasis have been associated with <jats:italic>Candida<\/jats:italic> infection and other serious infections. It is, however, necessary to verify whether biologic agents increase the risk of <jats:italic>Candida<\/jats:italic> infection and serious infections and whether these risks vary among biologics. <jats:italic>Methods<\/jats:italic>. PubMed, EMBASE, and Cochrane Library were searched for eligible randomized controlled trials (RCTs) from their inception to December 2021. Results from individual RCT were pooled using Peto\u2019s method with a fixed\u2010effects model, and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> was calculated to assess the heterogeneity. A Cochrane collaboration tool was used to examine bias risk, and Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) were used to assess the quality of evidence. <jats:italic>Results<\/jats:italic>. This study included 48 published articles with data from 52 RCTs involving 27297 participants. The anti\u2010interleukin (IL)\u201017 agents (95% confidence interval (CI)\u2009=\u20091.54\u20133.45, <jats:italic>P<\/jats:italic> &lt; 0.0001) and anti\u2010IL\u201012\/23 agents (95% CI\u2009=\u20091.69\u20133.83, <jats:italic>P<\/jats:italic> &lt; 0.0001) were associated with an increased risk of <jats:italic>Candida<\/jats:italic> infection compared with placebos, but there was no difference in <jats:italic>Candida<\/jats:italic> infection risk between anti\u2010IL\u201017 agents and tumor necrosis factor inhibitors (TNFi) (95% CI\u2009=\u20090.92\u20133.07, <jats:italic>P<\/jats:italic> = 0.09). There was no evidence that the biological agents increased the risk of serious infections in adult psoriasis (95% CI\u2009=\u20090.93\u20132.06, <jats:italic>P<\/jats:italic> = 0.11) or that the biologics differed in the risk of serious infections. <jats:italic>Conclusions<\/jats:italic>. Our results indicated that anti\u2010IL\u201017 agents, especially secukinumab, were associated with the increased risk of <jats:italic>Candida<\/jats:italic> infection. The clinically used biological agents did not increase the risk of serious infections.<\/jats:p>","DOI":"10.1155\/2022\/2442603","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T15:35:10Z","timestamp":1663774510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk of <i>Candida<\/i> Infection and Serious Infections in Patients with Moderate\u2010to\u2010Severe Psoriasis Receiving Biologics: A Systematic Review and Meta\u2010Analysis of Randomized Controlled 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