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There is a limit to the therapeutic effects of the available asthma drugs on neutrophilic asthma. Shegan Mahuang Decoction (SMD) is one of the representative traditional Chinese medicine (TCM) prescriptions for asthma, and it can effectively relieve the clinical symptoms of patients. However, the effect of SMD on the treatment of neutrophilic asthma remains unknown. In this study, a mouse model of neutrophilic asthma induced by lipopolysaccharide (LPS)\/ovalbumin (OVA) was established, and the effect of a modified SMD prescription on the model was evaluated. After treatment, SMD was demonstrated to be therapeutically effective on asthmatic mice via airway resistance detection and lung pathology and was able to affect cytokine levels in vivo. Further experiments verified that SMD regulated the expression of mitochondrial function proteins in bronchoalveolar lavage fluid (BALF) exosomes. The results demonstrate that SMD confers a therapeutic effect on a neutrophilic asthma mouse model, and it may reduce neutrophil airway inflammation by regulating myeloid-derived regulatory cell (MDRC) function and airway exosome mitochondrial function.<\/jats:p>","DOI":"10.1155\/2022\/2477510","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T23:20:09Z","timestamp":1671492009000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Shegan Mahuang Decoction May Reduce Airway Inflammation in Neutrophilic Asthmatic Mice by Improving the Mitochondrial Function of Bronchoalveolar Lavage Fluid Exosomes"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hui-na","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children\u2019s Hospital of Chongqing Medical University, Chongqing, Chongqing Key Laboratory of Pediatrics, China"},{"name":"Department of Pediatrics, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-3222","authenticated-orcid":true,"given":"Zhou","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children\u2019s Hospital of Chongqing Medical University, Chongqing, Chongqing Key Laboratory of Pediatrics, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 958 Hospital of Army PLA, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children\u2019s Hospital of Chongqing Medical University, Chongqing, Chongqing Key Laboratory of Pediatrics, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00128.2016"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7808576"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3VMR1214-600RR"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.02.011"},{"key":"5","article-title":"Mitochondria as Signaling Organelles","volume":"34","author":"N. 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