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Oxidative stress and mitochondrial dysfunction have been identified as significant abnormalities in septic cardiomyopathy. However, specific treatments are rare. This study aims to investigate the impact of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxybutyrate (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010OHB) on septic cardiomyopathy and explore the underlying mechanism(s). We found that pretreatment of D\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxybutyrate\u2010(R)\u20101,3 butanediol monoester (ketone ester, 3\u2009mg\/g body weight, once daily) by gavage for three days elevated the levels of ketone bodies, especially that of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxybutyrate (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010OHB) in the circulation and mouse hearts, which exerted a protective effect against lipopolysaccharide (LPS, 20\u2009mg\/kg)\u2010induced septic cardiomyopathy in mice. In addition, an LPS\u2010stimulated macrophage\u2010conditioned medium (MCM) was used to mimic the pathological process of septic cardiomyopathy. Mechanistically,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010OHB alleviated myocardial oxidative stress and improved mitochondrial respiratory function through the antioxidant FoxO3a\/MT2 pathway activated via histone deacetylase (HDAC) inhibition, which ultimately enhanced heart performance in septic cardiomyopathy. Our results, therefore, suggested an unappreciated critical role of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010OHB in septic heart protection as well as highlighted the potential of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010OHB as a simple remedy for the septic cardiomyopathy population.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2513837","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T20:05:08Z","timestamp":1647633908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Ketone Body\n                    <i>\u03b2<\/i>\n                    \u2010Hydroxybutyrate Prevents Myocardial Oxidative Stress in Septic Cardiomyopathy"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-870X","authenticated-orcid":false,"given":"Liwei","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maodi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiteng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-1540","authenticated-orcid":false,"given":"Xintian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-3090","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.08.1037"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00492-2"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000177"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17687"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18147598"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101771"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5985209"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.011"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13668-3"},{"key":"e_1_2_10_12_2","first-page":"93","article-title":"Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart","volume":"6","author":"Madungwe N. 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