{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:07:02Z","timestamp":1791000422318,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Foundation for Post Doctorate Research of the Beijing","award":["2017-ZZ-123"],"award-info":[{"award-number":["2017-ZZ-123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,2,27]]},"abstract":"<jats:p>Objective. We aimed to evaluate the clinical characteristics and long-term prognosis of brain arteriovenous malformations (bAVMs) treated with multimodality management of one-staged hybrid operation. Methods. We identified bAVM patients treated with one-staged hybrid operation from a multicenter prospective cohort study (NCT03774017) between January 2016 and June 2020. Patients were divided into unruptured and ruptured groups by the hemorrhagic presentation. Long-term (&gt;12 months) neurological disability, postoperative complications of stroke, and nidus obliteration were evaluated and compared between groups. Prognostic predictors associated with outcomes were analyzed. Results. A total of 130 patients were identified in the study receiving one-staged hybrid operations, including 61 unruptured cases and 69 ruptured cases. Mean age was 29.1 years old, with 78 (60.0%) being male. Patients included in the study were followed up for a mean period of 37.4 (11.07) months. The annual hemorrhagic risk was 4.2% per year. Thirteen postoperative stroke events were detected in 11 patients (8.5%). Long-term disability occurred in 6.9% of cases, and 86.2% of patients experienced an unchanged or improved neurological status at the last follow-up. All patients achieved complete obliteration on follow-up angiographies. Increased AVM volume was associated with a higher risk of postoperative stroke (odds ratio (OR) 1.021, 95% confidence interval (CI) 1.006-1.037, and <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.006<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Poor neurological status (OR 6.461, 95% CI 1.309-31.889, and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.022<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and infratentorial location (OR 5.618, 95% CI 1.158-27.246, and <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.032<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) were independent predictors for long-term disability. Conclusions. One-staged hybrid operation of embolization combined microsurgical resection can be performed as a safe and effective strategy for bAVM treatments. Long-term prognosis of complete obliteration with low rates of morbidity and mortality can be achieved. Unruptured and ruptured bAVMs acquired similar favorable outcomes after the multimodality treatment.<\/jats:p>","DOI":"10.1155\/2022\/2559004","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:46:55Z","timestamp":1646009215000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Multimodality Treatment of Brain Arteriovenous Malformations with One-Staged Hybrid Operation: Clinical Characteristics and Long-Term Prognosis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yuanfeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-0256","authenticated-orcid":true,"given":"Chaofan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hancheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-747X","authenticated-orcid":true,"given":"Weijian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurosurgery, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp067192"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709449"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000688"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.05.241"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2020.1765972"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010382"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2020.03.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.1.0017"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2012.01706.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3171\/2014.6.FOCUS14165"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000134"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000093198.98170.D4"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31820b4f1c"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.21.2644"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1289-3"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.570198"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3171\/2012.3.JNS111405"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.01.166"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1632"},{"issue":"1","key":"21","doi-asserted-by":"crossref","DOI":"10.1136\/neurintsurg-2019-015115","article-title":"Curative treatment for low-grade arteriovenous malformations","volume":"12","author":"A. Wang","year":"2019","journal-title":"Journal of NeuroInterventional Surgery"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000333293.74986.e5"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-018-2140-z"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.FOCUS14160"},{"issue":"6","key":"25","article-title":"Cerebral hyperemia after arteriovenous malformation resection is related to \"breakthrough\" complications but not to feeding artery pressure","volume":"38","author":"W. L. Young","year":"1996","journal-title":"The Columbia University Arteriovenous Malformation Study Project. Neurosurgery"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-008-0382-x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3171\/2014.6.FOCUS14228"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1179\/1743132812Y.0000000044"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000185723.98111.75"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.1.0060"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004292"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1873-z"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001191"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2011-010198"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000367555.16733.E1"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/2559004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/2559004.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/2559004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:46:59Z","timestamp":1646009219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/2559004\/"}},"subtitle":[],"editor":[{"given":"Liangqun","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,27]]},"references-count":36,"alternative-id":["2559004","2559004"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2559004","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,27]]}}}