{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:10:11Z","timestamp":1767168611915,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:p>\n                    Background. To explore the risk factors of gastrointestinal hemorrhage and\/or cerebral infarction complications in liver cirrhosis and provide evidence for early prevention, clinical diagnosis, and treatment of liver cirrhosis. Methods. 200 liver cirrhosis patients were analyzed: liver cirrhosis (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>78<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), liver cirrhosis complicated with cerebral infarction (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>43<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ), liver cirrhosis complicated with gastrointestinal hemorrhage (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>n<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>57<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ), and liver cirrhosis complicated with gastrointestinal hemorrhage and cerebral infarction (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>n<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>22<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). The incidence of disease in each group of patients at different times was calculated. Multivariate logistic regression was used to analyze the risk factors of liver cirrhosis patients with gastrointestinal hemorrhage and cerebral infarction. After 12 months of follow-up, the mortality rate of each group was calculated. Results. The incidences of gastrointestinal hemorrhage, cerebral infarction, and gastrointestinal hemorrhage combined with cerebral infarction in patients with liver cirrhosis were 21.5%, 28.5%, and 11%, respectively. The width of the portal vein, D-2 polymer, albumin (ALB), and hemoglobin (Hb) were predictors of gastrointestinal hemorrhage and cerebral infarction in patients with liver cirrhosis. Age, hypertension, bleeding history, infection, portal vein width, and D-2 polymer were confirmed as risk factors for gastrointestinal hemorrhage and cerebral infarction in patients with liver cirrhosis. ALB and Hb were independent protective factors. Patients with liver cirrhosis and gastrointestinal hemorrhage with cerebral infarction had the worst survival. Conclusion. Age, hypertension, bleeding history, infection, portal vein width, and D-2 polymer are all independent risk factors for gastrointestinal bleeding and cerebral infarction, while ALB and Hb are independent protective factors.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2566746","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T22:35:07Z","timestamp":1659652507000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Analysis of Liver Cirrhosis Patients with Cerebral Infarction and\/or Gastrointestinal Hemorrhage: A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2022","author":[{"given":"Dianqiang","family":"Lu","sequence":"first","affiliation":[{"name":"Center of Digestive Endoscopy, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center of Digestive Endoscopy, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuezhen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Huaiyin Hospital of Huai\u2019an City, Huaian 223300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-4425","authenticated-orcid":true,"given":"Zhiguang","family":"Sun","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine, Nanjing 210017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1504367"},{"issue":"12","key":"2","first-page":"759","article-title":"Cirrhosis: diagnosis and management","volume":"100","author":"A. 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