{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:39:19Z","timestamp":1790959159417,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Medical and Health Platform Project","award":["2021KY569"],"award-info":[{"award-number":["2021KY569"]}]},{"name":"Zhejiang Medical and Health Platform Project","award":["LY21H290001"],"award-info":[{"award-number":["LY21H290001"]}]},{"name":"Zhejiang Medical and Health Platform Project","award":["81973805"],"award-info":[{"award-number":["81973805"]}]},{"name":"Natural Science Foundation Project of Zhejiang Province","award":["2021KY569"],"award-info":[{"award-number":["2021KY569"]}]},{"name":"Natural Science Foundation Project of Zhejiang Province","award":["LY21H290001"],"award-info":[{"award-number":["LY21H290001"]}]},{"name":"Natural Science Foundation Project of Zhejiang Province","award":["81973805"],"award-info":[{"award-number":["81973805"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021KY569"],"award-info":[{"award-number":["2021KY569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LY21H290001"],"award-info":[{"award-number":["LY21H290001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973805"],"award-info":[{"award-number":["81973805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2022,1,29]]},"abstract":"<jats:p>Background. Curcumin is a polyphenol plant-derived compound with anti-inflammatory, antioxidant stress, and anticancer properties that make it have the potential to treat cancer cachexia. However, the role of it in breast cancer cachexia remains unclear. Methods. The 4T1 cells were subcutaneously injected into BALB\/c mice to induce breast cancer cachexia. After tumor formation, the animals were divided into groups and given curcumin or saline interventions. The therapeutic effect of curcumin on breast cancer cachexia was characterized by tumor growth, changes in body mass and gastrocnemius mass, muscle function test, histopathology, and serum nutrition indexes. Mitochondrial function in muscle tissue was observed by transmission electron microscopy and ATP detection, muscle inflammatory factors were detected by ELISA, muscle differential metabolites were detected by 1HNMR metabolomics, and the muscle tissue ubiquitination levels and NF-KB expression were also analyzed by RT-qPCR and Western blot. Results. Dynamic in vivo bioluminescence imaging find that curcumin inhibited the growth of tumor in triple-negative breast cancer- (TNBC-) bearing mice, slowed down the loss of body weight and gastrocnemius weight, corrected the mitochondrial dysfunction and malnutrition status, and also significantly improved skeletal muscle function. ELISA analysis found that the level of inflammatory factors in muscle tissue was reduced. 1HNMR metabolomics analysis suggested that curcumin could regulate energy metabolism pathways. RT-qPCR and Western blot analysis found that the expression of myogenic factor myogenin was increased and the expression of myodegradation factor myostatin was decreased in the gastrocnemius; the level of ubiquitination and activation of the NF-\u03baB pathway were also declined. Conclusions. Curcumin reduces ubiquitination, inflammation in skeletal muscle by regulating the NF-KB\/UPS axis and improves muscle malignant metabolic phenotype and mitochondrial dysfunction, to alleviate muscle atrophy and loss of function in mice with breast cancer cachexia.<\/jats:p>","DOI":"10.1155\/2022\/2567150","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T20:20:09Z","timestamp":1643487609000},"page":"1-18","source":"Crossref","is-referenced-by-count":27,"title":["Curcumin Targeting NF-\u03baB\/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jin","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China"},{"name":"Department of Oncology, Hospital Affiliated to Shaanxi University of Chinese Medicine, Xianyang 712000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The Second Hospital Affiliated to Air Force Medical University, Xi\u2019an 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Cancer Hospital of the University of Chinese Academy of Sciences\/Zhejiang Cancer Hospital, Hangzhou 310022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Li","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiao","family":"Ye","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, Cancer Hospital of the University of Chinese Academy of Sciences\/Zhejiang Cancer Hospital, Hangzhou 310022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-4433","authenticated-orcid":true,"given":"Qinghua","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Cancer Hospital of the University of Chinese Academy of Sciences\/Zhejiang Cancer Hospital, Hangzhou 310022, China"},{"name":"Key Laboratory of Traditional Chinese Medicine Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-4230","authenticated-orcid":true,"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"106","article-title":"Current approaches in treatment of triple-negative breast cancer","volume":"12","author":"H. A. Wahba","year":"2015","journal-title":"Cancer Biology & Medicine"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/217185"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.011"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00218"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12357"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.06.020"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018101051"},{"key":"8","first-page":"489","article-title":"Definition and classification of cancer cachexia: an international consensus","author":"K. Fearon"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246267"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0164"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.021"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9779"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2307"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251541198"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00341-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00028.2019"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-010-0209-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00398.2011"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02347-2"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2013.08.005"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091222"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12360"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.021"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509993667"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2020.1783721"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420174"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.209"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4104-6"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.2741\/A602"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600074"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00390-2"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4252"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.08.008"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan5662"},{"issue":"1","key":"37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/ijms21010088","article-title":"Increased adenine nucleotide degradation in skeletal muscle atrophy","volume":"21","author":"S. G. Miller","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108824"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12788"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00288-1"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061825"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31812"},{"key":"43","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-10-6020-5_11","volume-title":"Metabolic changes during cancer cachexia pathogenesis","author":"N. Shyh-Chang","year":"2017"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1760425"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.52"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00211-4"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00402.2011"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.027"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/2567150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/2567150.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/2567150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T20:20:18Z","timestamp":1643487618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2022\/2567150\/"}},"subtitle":[],"editor":[{"given":"Xiaolu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,29]]},"references-count":48,"alternative-id":["2567150","2567150"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2567150","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,29]]}}}