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The aim of the study is to explore the molecular mechanism of activating blood circulation and dispersing stasis herbs in the treatment of pre-eclampsia with Chuanxiong Rhizoma-Radix Salvia miltiorrhiza. Methods. The chemical composition and targets of Chuanxiong Rhizoma-Radix Salvia miltiorrhiza were retrieved from the TCMSP database, and a PPI network was constructed for common genes. Subsequently, a graph of the \u201cactive component-target-action pathway\u201d was plotted by Cytoscape 3.7.2 and a KEGG pathway enrichment was performed using the R language cluster profiler package. Molecular docking was conducted between the top five PPI targets of Chuanxiong Rhizoma-Radix Salvia miltiorrhiza. Results. According to network pharmacology, there were 32 target genes, 60 active components, and 59 pathways in Chuanxiong Rhizoma-Radix Salvia miltiorrhiza, and its most evident effects were exerted on G-protein-coupled amine receptors and the neuroactive ligand-receptor interaction signaling pathway. Molecular docking indicated that the target protein had a good binding ability with the drugs. Conclusion. Chuanxiong Rhizoma-Radix Salvia miltiorrhiza have therapeutic effects in pre-eclampsia, as confirmed by the results of molecular biology analysis. Thus, the Chuanxiong Rhizoma-Radix Salvia miltiorrhiza regimen provides a basis for the treatment of pre-eclampsia using traditional Chinese medicine.<\/jats:p>","DOI":"10.1155\/2022\/2568008","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T17:05:07Z","timestamp":1662570307000},"page":"1-13","source":"Crossref","is-referenced-by-count":1,"title":["Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of \u201cChuanxiong Rhizoma: Radix Salviae miltiorrhizae\u201d Herb Couples in the Treatment of Preeclampsia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jing","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Tongde Hospital of Zhejiang, Hangzhou 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-6948","authenticated-orcid":true,"given":"Guang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Tongde Hospital of Zhejiang, Hangzhou 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/uog.21867","article-title":"Impact of new definitions of pre-eclampsia on incidence and performance of first-trimester screening","volume":"55","author":"N. 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