{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:34:44Z","timestamp":1789907684079,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673843"],"award-info":[{"award-number":["81673843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008697","name":"University of Karachi","doi-asserted-by":"publisher","award":["81673843"],"award-info":[{"award-number":["81673843"]}],"id":[{"id":"10.13039\/100008697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:p>\n                    Background. In the present study, we systematically evaluated the effects of Traditional Chinese Medicine (TCM) on androgenetic alopecia (AGA) in rodent models (rats and mice) to provide potential evidence for the treatment of AGA by TCM. Methods. Previous research papers focusing on the treatment of AGA by TCM were retrieved from various electronic databases (PubMed, Embase, The Cochrane Library, CNKI, Vip, Wanfang data, and CBM) up to October 30, 2021. Screening of the literature was performed independently, and data were extracted and assessed. A meta-analysis was performed using RevMan 5.3 software. Results. When compared with the model groups, a group of C57BL\/6 mice treated with TCM showed an increase in the total number of hair follicles (mean difference [MD]\u2009=\u200911.99, 95% confidence interval [CI] [5.94,18.03],\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.0001<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), as well as a decrease in serum testosterone (T) level (MD\u2009=\u2009\u22121.10, 95% CI [\u22121.43, \u22120.78],\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.00001<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ), skin discoloration time (MD\u2009=\u2009\u22122.93, 95% CI [\u22124.03, \u22121.84],\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.00001<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ), and skin hair growth time (MD\u2009=\u2009\u22123.16, 95% CI [\u22124.16, \u22122.16],\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.00001<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). Terminal hair\/vellus hair also increased in TCM-treated AGA animals (MD\u2009=\u20093.02, 95% CI [2.05, 3.98],\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.00001<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). No significant difference was found in serum estradiol (E2) level, skin tissue E2 level, or skin tissue T level between the TCM-treated group and the model group. Conclusion. TCM can increase the total number of hair follicles and terminal hair\/vellus hair ratio, and reduce skin discoloration time and skin hair growth time in AGA animal models. These effects may be related to the reduction of the serum T level in AGA animals. These conclusions need to be verified by high-quality studies as the current analysis may be affected by the number and quality of the studies identified.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2588608","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T13:35:09Z","timestamp":1665495309000},"page":"1-19","source":"Crossref","is-referenced-by-count":3,"title":["Traditional Chinese Medicine Treatment for Androgenetic Alopecia Based on Animal Experiments: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-4508","authenticated-orcid":true,"given":"Yanbo","family":"Liang","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nururshopa Eskander","family":"Shazada","sequence":"additional","affiliation":[{"name":"University of South Bohemia, Ceske Budejovice, Vodnany, Ceske Budejovic 38925, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-4052","authenticated-orcid":true,"given":"Jianlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1826-8"},{"issue":"3","key":"2","first-page":"307","article-title":"Clinical efficacy observation of abdominal acupuncture combined with moxibustion in the treatment of male seborrheic alopecia with deficiency of qi and blood","volume":"26","author":"J. 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