{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:58:32Z","timestamp":1785473912661,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,7,18]]},"abstract":"<jats:p>Medicinal plants have been crucial in treating various chronic ailments since ancient times. The objective of this study was to evaluate in vitro pharmacological properties of petroleum ether, chloroform, and ethyl acetate soluble fractions of ethanolic extract (leaf, bark, and root) of Heritiera fomes Buch. Ham., including the phytochemical screening of the plant. Thrombolytic and antiarthritic properties were assessed through the clot lysis and protein denaturation experimental method, correspondingly. Anthelmintic and insecticidal activities were studied against Pheretima posthuma and Tribolium castaneum, respectively. The phytochemical analysis exhibited numerous active phytochemicals in different solvent fractions. In thrombolytic investigation, among all crude extracts, ethanolic leaf extract showed the highest 33.12\u2009\u00b1\u20097.52% clot lysis as compared to standard streptokinase (67.77\u2009\u00b1\u20099.78%). In antiarthritic assay, all the tested samples exhibited noteworthy protein denaturation in dose-dependent manner (100\u2013500\u2009\u03bcg\/mL), whereas the utmost percentage inhibition was noticed for chloroform extract of roots (63.28\u2009\u00b1\u20095.96% at 500\u2009\u03bcg\/mL). All crude extracts exhibited a significant anthelmintic activity in different concentrations (25\u201375\u2009mg\/mL) and revealed paralysis and death of earthworms in comparison with albendazole; ethanolic extract of the bark was found to be more potent at the highest dose. For the insecticidal test, ethanolic extract of the leaf showed the utmost mortality rate (73%). The outcomes of the investigation confirmed the potential thrombolytic, antiarthritic, anthelmintic, and insecticidal activities of the different extracts of H. fomes, and hence, advanced studies on the isolation and identification of active phytocompounds are highly needed for new drug development.<\/jats:p>","DOI":"10.1155\/2022\/2594127","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T20:50:07Z","timestamp":1658177407000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical and Pharmacological Profiling of Heritiera fomes Buch. Ham. Deciphered Thrombolytic, Antiarthritic, Anthelmintic, and Insecticidal Potentialities via In Vitro Approach"],"prefix":"10.1155","volume":"2022","author":[{"given":"Farhana Alam","family":"Ripa","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Brac University, 41-Pacific Tower, Mohakhali, Dhaka 1212, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-207X","authenticated-orcid":true,"given":"Md. Jamal","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Luthfun","family":"Nesa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miss Sharmin","family":"Zahan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-3093","authenticated-orcid":true,"given":"Arpita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-9128","authenticated-orcid":true,"given":"Saad","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Almehmadi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Abdulaziz","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2174\/1875692116666180419154033"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/life12010060"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.15406\/hpmij.2019.03.00165"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27134024"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1021\/np200906s"},{"key":"6","volume-title":"Traditional Medicines: Global Situation, Issues and Challenges","author":"WHO","year":"2011"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4740246"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112932"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8288818"},{"issue":"2","key":"10","first-page":"157","article-title":"Pharmacognostic profile and phytochemical investigation of Pluchea Lanceolata oliver and hiern. in vivo and in vitro","volume":"22","author":"D. 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