{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:46:13Z","timestamp":1791830773342,"version":"4.3.4"},"reference-count":288,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["32171231"],"award-info":[{"award-number":["32171231"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["81920108030"],"award-info":[{"award-number":["81920108030"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["31800706"],"award-info":[{"award-number":["31800706"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>According to numerous animal studies, adverse environmental stimuli, including physical, chemical, and biological factors, can cause low\u2010grade chronic inflammation and subsequent tumor development. Human epidemiological evidence has confirmed the close relationship between chronic inflammation and tumorigenesis. However, the mechanisms driving the development of persistent inflammation toward tumorigenesis remain unclear. In this study, we assess the potential role of reactive oxygen species (ROS) and associated mechanisms in modulating inflammation\u2010induced tumorigenesis. Recent reports have emphasized the cross\u2010talk between oxidative stress and inflammation in many pathological processes. Exposure to carcinogenic environmental hazards may lead to oxidative damage, which further stimulates the infiltration of various types of inflammatory cells. In turn, increased cytokine and chemokine release from inflammatory cells promotes ROS production in chronic lesions, even in the absence of hazardous stimuli. Moreover, ROS not only cause DNA damage but also participate in cell proliferation, differentiation, and apoptosis by modulating several transcription factors and signaling pathways. We summarize how changes in the redox state can trigger the development of chronic inflammatory lesions into tumors. Generally, cancer cells require an appropriate inflammatory microenvironment to support their growth, spread, and metastasis, and ROS may provide the necessary catalyst for inflammation\u2010driven cancer. In conclusion, ROS bridge the gap between chronic inflammation and tumor development; therefore, targeting ROS and inflammation represents a new avenue for the prevention and treatment of cancer.<\/jats:p>","DOI":"10.1155\/2022\/2606928","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T05:20:19Z","timestamp":1656480019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-3049","authenticated-orcid":false,"given":"Weihua","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-8916","authenticated-orcid":false,"given":"Yongmei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-8963","authenticated-orcid":false,"given":"Zi","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-6320","authenticated-orcid":false,"given":"Jiangzheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-4846","authenticated-orcid":false,"given":"Jie","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-3365","authenticated-orcid":false,"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-791X","authenticated-orcid":false,"given":"Gang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-6392","authenticated-orcid":false,"given":"Jiuzhou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-5914","authenticated-orcid":false,"given":"Yuhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-4353","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7509-1398","authenticated-orcid":false,"given":"Wenli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-2496","authenticated-orcid":false,"given":"Chunxu","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200307"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031912-114350"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0227-4"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199104000-00021"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236988"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01731"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071987"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.014"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3921"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30460-5"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.1155"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319696"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1676ED"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.04.008"},{"key":"e_1_2_12_16_2","first-page":"217","article-title":"Chronic inflammation and cancer","volume":"16","author":"Shacter E.","year":"2002","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102895"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12156"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.165"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.016"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/v9100304"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12518"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018825532059"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103458"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-0807"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.10.008"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.07.046"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30974-0"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030361"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/528S117a"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2018.07.002"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33012"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17598"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.09.001"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.06.003"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31891-8"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32470-X"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6855"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-1748-0"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.07802"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0604-9"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2021.04.001"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.05.023"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.11.014"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-016-4022-y"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00256"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03381-1"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.034"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0688-z"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1941285"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.11.005"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.04.005"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2513"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v12.i7.562"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7425"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8212"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.01.006"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1914-5"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2020_208"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29912"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1381-2"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5276130"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2020.04.004"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2016.03.004"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122085"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2017.08.003"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.07.011"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050275"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125162"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.07.030"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa388"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-0568"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0633-x"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.07.005"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0375-y"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.11.003"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00553"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.042"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0067-5"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225563"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034348"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1345412"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0286-3"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.149"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14926"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.05.020"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01187-y"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4785"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21330"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101761"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949799"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12453"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5698931"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102707"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103285"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13537"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.022"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.030"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2019.7086"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.08.021"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.04.018"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.11.009"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0098"},{"key":"e_1_2_12_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3803"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.50"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.009"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1320"},{"key":"e_1_2_12_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.12.002"},{"key":"e_1_2_12_117_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7818"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.554725"},{"key":"e_1_2_12_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad6095"},{"key":"e_1_2_12_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.12.006"},{"key":"e_1_2_12_121_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10101429"},{"key":"e_1_2_12_122_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1985"},{"key":"e_1_2_12_123_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21407"},{"key":"e_1_2_12_124_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006540"},{"key":"e_1_2_12_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00574-3"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.715234"},{"key":"e_1_2_12_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.015"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22395"},{"key":"e_1_2_12_129_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0772-z"},{"key":"e_1_2_12_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0222-4"},{"key":"e_1_2_12_131_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2990"},{"key":"e_1_2_12_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.01.025"},{"key":"e_1_2_12_133_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1737"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182124"},{"key":"e_1_2_12_135_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210720143721"},{"key":"e_1_2_12_136_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1556064"},{"key":"e_1_2_12_137_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010039"},{"key":"e_1_2_12_138_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098259"},{"key":"e_1_2_12_139_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02936"},{"key":"e_1_2_12_140_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02472-z"},{"key":"e_1_2_12_141_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-0843-1"},{"key":"e_1_2_12_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2019.102673"},{"key":"e_1_2_12_143_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150514105741"},{"key":"e_1_2_12_144_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.25583"},{"key":"e_1_2_12_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.010"},{"key":"e_1_2_12_146_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051296"},{"key":"e_1_2_12_147_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112599"},{"key":"e_1_2_12_148_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-019-09949-5"},{"key":"e_1_2_12_149_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051218"},{"key":"e_1_2_12_150_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204173"},{"key":"e_1_2_12_151_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8127362"},{"key":"e_1_2_12_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.006"},{"key":"e_1_2_12_153_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2858"},{"key":"e_1_2_12_154_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122085"},{"key":"e_1_2_12_155_2","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2019.1695975"},{"key":"e_1_2_12_156_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.97105s51089"},{"key":"e_1_2_12_157_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/58.1.208"},{"key":"e_1_2_12_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2019.01.005"},{"key":"e_1_2_12_159_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0064-6"},{"key":"e_1_2_12_160_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2016.0109"},{"key":"e_1_2_12_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(92)90047-4"},{"key":"e_1_2_12_162_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi181"},{"key":"e_1_2_12_163_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22061014"},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914nc392_19"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.22176"},{"key":"e_1_2_12_166_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081808"},{"key":"e_1_2_12_167_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00392-7"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000506"},{"key":"e_1_2_12_169_2","doi-asserted-by":"publisher","DOI":"10.1539\/joh.13-0231-OA"},{"key":"e_1_2_12_170_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00406"},{"key":"e_1_2_12_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.09.008"},{"key":"e_1_2_12_172_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092647"},{"key":"e_1_2_12_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105474"},{"key":"e_1_2_12_174_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02838-19"},{"key":"e_1_2_12_175_2","first-page":"175","article-title":"A discussion of mechanisms of NO genotoxicity: implication of inhibition of DNA repair proteins","volume":"131","author":"Laval F.","year":"1997","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2014.05.096"},{"key":"e_1_2_12_177_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp256"},{"key":"e_1_2_12_178_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-0118"},{"key":"e_1_2_12_179_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.401"},{"key":"e_1_2_12_180_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5960"},{"key":"e_1_2_12_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.04.021"},{"key":"e_1_2_12_182_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20255"},{"key":"e_1_2_12_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.03.018"},{"key":"e_1_2_12_184_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.23723"},{"key":"e_1_2_12_185_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1166318"},{"key":"e_1_2_12_186_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S219247"},{"key":"e_1_2_12_187_2","first-page":"2710","article-title":"Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression","volume":"20","author":"Diao Q. X.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_188_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201804161"},{"key":"e_1_2_12_189_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524022666211222161637"},{"key":"e_1_2_12_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.047"},{"key":"e_1_2_12_191_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00256.2018"},{"key":"e_1_2_12_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.05.018"},{"key":"e_1_2_12_193_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2019.7206"},{"key":"e_1_2_12_194_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008126"},{"key":"e_1_2_12_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.07.012"},{"key":"e_1_2_12_196_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06268-2"},{"key":"e_1_2_12_197_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3391"},{"key":"e_1_2_12_198_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-00412-1"},{"key":"e_1_2_12_199_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_2_12_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2020.151073"},{"key":"e_1_2_12_201_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12095"},{"key":"e_1_2_12_202_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-017-9583-4"},{"key":"e_1_2_12_203_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5426"},{"key":"e_1_2_12_204_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.869"},{"key":"e_1_2_12_205_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4044"},{"key":"e_1_2_12_206_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0379-0"},{"key":"e_1_2_12_207_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-664995"},{"key":"e_1_2_12_208_2","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.36"},{"key":"e_1_2_12_209_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03536-5"},{"key":"e_1_2_12_210_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01298-z"},{"key":"e_1_2_12_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.02.018"},{"key":"e_1_2_12_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188352"},{"key":"e_1_2_12_213_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081849"},{"key":"e_1_2_12_214_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-512749"},{"key":"e_1_2_12_215_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.15.16870"},{"key":"e_1_2_12_216_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.3053"},{"key":"e_1_2_12_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.02.029"},{"key":"e_1_2_12_218_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5068"},{"key":"e_1_2_12_219_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00665797"},{"key":"e_1_2_12_220_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030361"},{"key":"e_1_2_12_221_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.13716"},{"key":"e_1_2_12_222_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10822"},{"key":"e_1_2_12_223_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.108854"},{"key":"e_1_2_12_224_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1549-7"},{"key":"e_1_2_12_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2018.11.001"},{"key":"e_1_2_12_226_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00651"},{"key":"e_1_2_12_227_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.09.008"},{"key":"e_1_2_12_228_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7640547"},{"key":"e_1_2_12_229_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43142"},{"key":"e_1_2_12_230_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9640"},{"key":"e_1_2_12_231_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.11.022"},{"key":"e_1_2_12_232_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02229-6"},{"key":"e_1_2_12_233_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177801"},{"key":"e_1_2_12_234_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.02.015"},{"key":"e_1_2_12_235_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.169"},{"key":"e_1_2_12_236_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-013-9740-z"},{"key":"e_1_2_12_237_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14230"},{"key":"e_1_2_12_238_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-4028"},{"key":"e_1_2_12_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.004"},{"key":"e_1_2_12_240_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.02.001"},{"key":"e_1_2_12_241_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs249"},{"key":"e_1_2_12_242_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0272-6"},{"key":"e_1_2_12_243_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.729367"},{"key":"e_1_2_12_244_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0553-x"},{"key":"e_1_2_12_245_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072605"},{"key":"e_1_2_12_246_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-020-01792-z"},{"key":"e_1_2_12_247_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30289-4"},{"key":"e_1_2_12_248_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00003"},{"key":"e_1_2_12_249_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.05.006"},{"key":"e_1_2_12_250_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2019.1623880"},{"key":"e_1_2_12_251_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy174"},{"key":"e_1_2_12_252_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-112211-154330"},{"key":"e_1_2_12_253_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103792"},{"key":"e_1_2_12_254_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.184267"},{"key":"e_1_2_12_255_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10418"},{"key":"e_1_2_12_256_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.07.041"},{"key":"e_1_2_12_257_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00459-9"},{"key":"e_1_2_12_258_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.09.010"},{"key":"e_1_2_12_259_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1815"},{"key":"e_1_2_12_260_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403083101006"},{"key":"e_1_2_12_261_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120310"},{"key":"e_1_2_12_262_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404143301501"},{"key":"e_1_2_12_263_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1995.10718532"},{"key":"e_1_2_12_264_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408399509527684"},{"key":"e_1_2_12_265_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02075-4"},{"key":"e_1_2_12_266_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.03.002"},{"key":"e_1_2_12_267_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.01.021"},{"key":"e_1_2_12_268_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190123112647"},{"key":"e_1_2_12_269_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.05.005"},{"key":"e_1_2_12_270_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.037"},{"key":"e_1_2_12_271_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1263597"},{"key":"e_1_2_12_272_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0135-7"},{"key":"e_1_2_12_273_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051501"},{"key":"e_1_2_12_274_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay8707"},{"key":"e_1_2_12_275_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112553"},{"key":"e_1_2_12_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90416-3"},{"key":"e_1_2_12_277_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071544"},{"key":"e_1_2_12_278_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00718H"},{"key":"e_1_2_12_279_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.005"},{"key":"e_1_2_12_280_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad3740"},{"key":"e_1_2_12_281_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2511"},{"key":"e_1_2_12_282_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31268"},{"key":"e_1_2_12_283_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-12-201312170-00729"},{"key":"e_1_2_12_284_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020457"},{"key":"e_1_2_12_285_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.12.007"},{"key":"e_1_2_12_286_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.06.001"},{"key":"e_1_2_12_287_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1357533"},{"key":"e_1_2_12_288_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2021.104887"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/2606928.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/2606928.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/2606928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:56:10Z","timestamp":1748912170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/2606928"}},"subtitle":[],"editor":[{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":288,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/2606928"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2606928","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2606928"}}