{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:59:20Z","timestamp":1787540360477,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,1,10]]},"abstract":"<jats:p>Background. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and its incidence is obviously increasing. The NT5DC family has been shown to be involved in the progression of many tumors. However, the biological function of NT5DC family members in HCC is still not well understood. Methods. Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan\u2013Meier plotter, cBioPortal, GeneMANIA, Metascape, and TIMER were applied to assess the biological function of NT5DC family members in HCC. Results. Most of the NT5DC family members were highly expressed in HCC. High expression of NT5C2, NT5DC2, and NT5DC3 was closely associated with higher tumor stage and poor overall survival (OS). In addition, high NT5DC2 and NT5DC3 expression also predicted poor disease-free survival (DFS). Enrichment analysis revealed that the NT5DC family in HCC mainly involved the IMP metabolic process, purine ribonucleoside monophosphate metabolic process, and purine nucleoside monophosphate metabolic process. The expression of NT5DC family members was closely related to the infiltration of some immune cells, such as B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. Conclusion. Our findings provided new insights into the biological function and prognostic value of NT5DC family members in HCC.<\/jats:p>","DOI":"10.1155\/2022\/2607878","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T01:05:06Z","timestamp":1641863106000},"page":"1-13","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive Analysis of Prognostic Value and Immune Infiltration of the NT5DC Family in Hepatocellular Carcinoma"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-8751","authenticated-orcid":true,"given":"Rongqi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China"},{"name":"Department of Hepatobiliary Surgery, Foshan Hospital of Traditional Chinese Medical, Foshan 528000, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-8891","authenticated-orcid":true,"given":"Rongqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-3273","authenticated-orcid":true,"given":"Shiyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China"},{"name":"Department of Head and Neck Surgery, The Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-918X","authenticated-orcid":true,"given":"Wenbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-2690","authenticated-orcid":true,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-7561","authenticated-orcid":true,"given":"Dewei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1001683"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.64.7412"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2012.18.1.48"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5035"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01149-x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.040"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-018-9627-2"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16409"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11931"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2549-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s1476-5586(04)80047-2"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.05.002"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27521-y"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.cd-12-0095"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky311"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-17-0307"},{"issue":"9","key":"20","first-page":"748","article-title":"NT5C2 expression in children with acute leukemia and its clinical significance","volume":"36","author":"Y. 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