{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:40:12Z","timestamp":1789756812252,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2022,10,28]]},"abstract":"<jats:p>Aim. This study aimed to explore if supplementary lycopene tablets may help heart failure (HF) patients improve their lipid profile, BP, and the flow-mediated dilation (FMD) index for endothelial function. Methods. Fifty patients with ischemic HF with a reduced ejection fraction (HFrEF) were randomly assigned to one of two groups: the lycopene group which received 25\u2009mg lycopene tablets once a day for 8 weeks and the control group which received placebo tablets containing starch once a day for 8 weeks. Results. Our results showed that after two months, the amount of triglyceride (TG) and FMD improved significantly compared to the control, TG decreased (219.27 vs. 234.24), and the mean of FMD increased (5.68 vs. 2.95). Other variables, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density cholesterol (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP), showed no improvement. Also, only SBP and FMD showed intragroup improvement in the intervention group. In the intervention group, only SBP and FMD exhibited intragroup improvement. Conclusions. It can be concluded that supplementing with lycopene can enhance endothelial function and reduce the TG levels in ischemic HFrEF patients. However, it had no positive effect on BP, TC, LDL-C, or HDL-C. Trial Registration. This clinical trial was registered at the Iranian Registry of Clinical Trials with IRCT registration number: IRCT20210614051574N4.<\/jats:p>","DOI":"10.1155\/2022\/2610145","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T01:20:06Z","timestamp":1667006406000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Lycopene Supplementation on Some Cardiovascular Risk Factors and Markers of Endothelial Function in Iranian Patients with Ischemic Heart Failure: A Randomized Clinical Trial"],"prefix":"10.1155","volume":"2022","author":[{"given":"Bahareh","family":"Karimian","sequence":"first","affiliation":[{"name":"Chamran Cardiovascular Medical and Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-5223","authenticated-orcid":true,"given":"Azam","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Chamran Cardiovascular Medical and Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Mohammadsharifi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-7128","authenticated-orcid":true,"given":"Kiyan","family":"Heshmat-Ghahdarijani","sequence":"additional","affiliation":[{"name":"Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Rejali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Islamic Azad University, Falavarjan Branch, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-2393","authenticated-orcid":true,"given":"Davood","family":"Shafie","sequence":"additional","affiliation":[{"name":"Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2712-3839","authenticated-orcid":true,"given":"Atefeh","family":"Amerizadeh","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-5558","authenticated-orcid":true,"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"55","article-title":"Assessment of the quality of life in elderly and senile age patients with chronic heart failure","volume":"11","author":"O. A. Osipova","year":"2022","journal-title":"Evidence Based Care"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2016.1264696"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.10.030"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2021.100902"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.830984"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23429"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2016.46.5.688"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4103\/jnsbm.jnsbm_53_21"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01204-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-019-0132-x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2018.12.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.06.030"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy069"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.801827"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15020959"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.ijpvm_112_17"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.174516"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3218605"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.169"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.734"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.food.102308.124120"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1159\/000342077"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-998-0295-6"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222701011"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153512"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093696"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.112.972240"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01746-6"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0b013e32835c1d01"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6381380"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.14.0887"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.11.018"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15833"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.01.009"},{"issue":"5","key":"36","first-page":"415","article-title":"Effect of lycopene from cooked tomatoes on serum antioxidant enzymes, lipid peroxidation rate and lipid profile in coronary heart disease","volume":"48","author":"K. S. C. Bose","year":"2007","journal-title":"Singapore Medical Journal"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20200804"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2713511"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020232"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2017.07.002"},{"issue":"1","key":"41","first-page":"244","article-title":"Effect of lycopene on the vascular endothelial function and expression of inflammatory agents in hyperhomocysteinemic rats","volume":"16","author":"X. Liu","year":"2007","journal-title":"Asia Pacific Journal of Clinical Nutrition"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2022\/2610145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2022\/2610145.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2022\/2610145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T01:20:10Z","timestamp":1667006410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crp\/2022\/2610145\/"}},"subtitle":[],"editor":[{"given":"Stefan","family":"Simovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":41,"alternative-id":["2610145","2610145"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2610145","relation":{},"ISSN":["2090-0597","2090-8016"],"issn-type":[{"value":"2090-0597","type":"electronic"},{"value":"2090-8016","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,28]]}}}