{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:55:07Z","timestamp":1753883707077,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2022,2,18]]},"abstract":"<jats:p>Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disease characterized by the formation of cutaneous and visceral telangiectasias and arteriovenous malformations (AVM). Multiple organs may be affected, including the nasal mucosa, skin, lungs, gastrointestinal tract, and brain. The following case highlights a unique manifestation of HHT in a patient with a gastrointestinal hemorrhage and epistaxis, resulting in hyperammonemia and diffuse cerebral edema and herniation. Clinicians should be aware of this potential complication in such patients and initiate ammonia-reducing agents early to avoid this devastating consequence.<\/jats:p>","DOI":"10.1155\/2022\/2612544","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T05:05:09Z","timestamp":1645247109000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Diffuse Cerebral Edema and Impending Herniation Complicating Hepatic Encephalopathy in Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-0022","authenticated-orcid":true,"given":"Charisma","family":"Mylavarapu","sequence":"first","affiliation":[{"name":"Houston Methodist Department of Medicine, Houston Methodist Hospital, 6550 Fannin St, Suite 1001, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Lu","sequence":"additional","affiliation":[{"name":"Houston Methodist Department of Medicine, Houston Methodist Hospital, 6550 Fannin St, Suite 1001, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan A.","family":"Burns","sequence":"additional","affiliation":[{"name":"Houston Methodist Cancer Center, Houston Methodist Hospital, 6445 Main St, Outpatient Center, Floor 24, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-9993","authenticated-orcid":true,"given":"Justin","family":"Samorajski","sequence":"additional","affiliation":[{"name":"Houston Methodist Department of Radiology, Houston Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Gotur","sequence":"additional","affiliation":[{"name":"Houston Methodist Department of Pulmonary & Critical Care Medicine, Houston Methodist Hospital, 6550 Fannin St, Suite 1001, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelty","family":"Baker","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital, 6560 Fannin St, Suite 1260, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-812532-8.00003-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0850-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10026"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.087452"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203720"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-8628(20000306)91:1<66::aid-ajmg12>3.0.co;2-p"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl037"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.7326\/M20-1443"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1633"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431305"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.12.022"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331407"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.35"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.2.4.361"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.12.008"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.54.179"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7573408"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.19080\/JAICM.2019.09.555784"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1085093"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1585-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03938.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/cld.445"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01320216"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3390\/nu10020140"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s4443"},{"article-title":"Cerebral herniation arising from hereditary hemorrhagic telangiectasia","year":"2021","author":"C. Mylavarapu","key":"27"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2022\/2612544.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2022\/2612544.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2022\/2612544.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T05:05:12Z","timestamp":1645247112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2022\/2612544\/"}},"subtitle":[],"editor":[{"given":"Simon Ching Shun","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":27,"alternative-id":["2612544","2612544"],"URL":"https:\/\/doi.org\/10.1155\/2022\/2612544","relation":{},"ISSN":["1687-9635","1687-9627"],"issn-type":[{"type":"electronic","value":"1687-9635"},{"type":"print","value":"1687-9627"}],"subject":[],"published":{"date-parts":[[2022,2,18]]}}}